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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccdc62repro29
reproductive mutant 29, JAX Reproductive Mutagenisis Program
MGI:3590192
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccdc62repro29/Ccdc62repro29 involves: C3HeB/FeJ * C57BL/6J MGI:3590200
ht2
 		Ccdc62repro29/Ccdc62+ involves: C3HeB/FeJ * C57BL/6J MGI:6116695


Genotype
MGI:3590200
hm1
Allelic
Composition		 Ccdc62repro29/Ccdc62repro29
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccdc62repro29 mutation (1 available); any Ccdc62 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:244081 )
N
• males show normal testes appearance, size and weight as well as normal sperm count
• females show normal fertility with no alteration in litter size
oligozoospermia ( J:92463 )
• low epididymal sperm concentration
teratozoospermia ( J:92463 , J:244081 )
• abnormally shaped sperm heads with and without tails (J:92463)
• virtually all sperm malformed (J:244081)
abnormal sperm midpiece morphology ( J:244081 )
• enclosed within a cytoplasm bag
• wrapped around head
abnormal sperm head morphology ( J:244081 )
• flagellum midpiece wrapped around head
• enclosed within a cytoplasm bag
asthenozoospermia ( J:92463 , J:244081 )
• very low sperm motility (J:92463)
• motility of cauda epididymal sperm reduced to 5% of wild-type (J:244081)
decreased seminal vesicle weight ( J:92463 )
• low seminal vesicle weight
abnormal spermiogenesis ( J:92463 )
• abnormal spermatid head shape and low number of elongating spermatids
male infertility ( J:92463 , J:244081 )
• males are infertile and in vitro fertilization has very low success (J:92463)
• male infertility observed after 2 months mating with wild-type or heterozygous mutant females (J:244081)

cellular
oligozoospermia ( J:92463 )
• low epididymal sperm concentration
teratozoospermia ( J:92463 , J:244081 )
• abnormally shaped sperm heads with and without tails (J:92463)
• virtually all sperm malformed (J:244081)
abnormal sperm midpiece morphology ( J:244081 )
• enclosed within a cytoplasm bag
• wrapped around head
abnormal sperm head morphology ( J:244081 )
• flagellum midpiece wrapped around head
• enclosed within a cytoplasm bag
asthenozoospermia ( J:92463 , J:244081 )
• very low sperm motility (J:92463)
• motility of cauda epididymal sperm reduced to 5% of wild-type (J:244081)

endocrine/exocrine glands
decreased seminal vesicle weight ( J:92463 )
• low seminal vesicle weight




Genotype
MGI:6116695
ht2
Allelic
Composition		 Ccdc62repro29/Ccdc62+
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccdc62repro29 mutation (1 available); any Ccdc62 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:244081 )
N
• fertile when mated with homozygous mutant females
• litter size when mated with homozygous mutant females
• sperm count
• sperm motility
• sperm morphology




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory