Analysis Tools|
Allele Symbol Allele Name Allele ID |
Gad1tm1.1Tama targeted mutation 1.1, Nobuaki Tamamaki MGI:3590301 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• chorda tympani nerves response to sour tastants is lower than in wild-type mice
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• chorda tympani nerves response to sour tastants is lower than in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• cultured interneurons from brain slices exhibit reduced and slower cell migration to the olfactory bulb compared with wild-type interneurons
• at E13.5, Gad67-GFP+ interneurons in the rostral ventral forebrain exhibit decreased net rate of migration, shorter somal translocation, fewer translocation per hour, longer pauses, and fewer direction changes compared with wild-type interneurons
• at E15.5, migration of dorsal lateral ganglionic eminence-derived interneurons is disrupted compared to in wild-type mice
• at E18.5, cells in the anterior subventricular zone exhibit decreased migration to the olfactory bulb compared with wild-type cells
• mice exhibit ectopic streaks of Gad67(Gad1)-GFP+ interneurons extending radially from the anterior subventricular zone in the rostral cortex unlike in wild-type mice
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• at E14.5 and E17.5, mice exhibit fewer proliferation cells at the ventricular surface and increased proliferating cells at the cortical plate compared with wild-type mice
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• between E10.5 and E15.5, mice exhibit increased apoptosis throughout the brain and body compared with wild-type mice
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• cultured interneurons from brain slices exhibit reduced and slower cell migration to the olfactory bulb compared with wild-type interneurons
• at E13.5, Gad67-GFP+ interneurons in the rostral ventral forebrain exhibit decreased net rate of migration, shorter somal translocation, fewer translocation per hour, longer pauses, and fewer direction changes compared with wild-type interneurons
• at E15.5, migration of dorsal lateral ganglionic eminence-derived interneurons is disrupted compared to in wild-type mice
• at E18.5, cells in the anterior subventricular zone exhibit decreased migration to the olfactory bulb compared with wild-type cells
• mice exhibit ectopic streaks of Gad67(Gad1)-GFP+ interneurons extending radially from the anterior subventricular zone in the rostral cortex unlike in wild-type mice
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• at E14.5 and E17.5, mice exhibit fewer proliferation cells at the ventricular surface and increased proliferating cells at the cortical plate compared with wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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