Phenotypes associated with this allele

• Allele Symbol: Tg(Pim1-Il9)5Jcrd
• Allele Name: transgene insertion 5, Jean-Christophe Renauld
• Allele ID: MGI:3590500
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Pim1-Il9)5Jcrd/0	involves: BALB/c * FVB/N	MGI:3590505
tg2	Tg(Pim1-Il9)5Jcrd/0	involves: FVB/N	MGI:3716474

Genotype
MGI:3590505

tg1

• Allelic Composition: Tg(Pim1-Il9)5Jcrd/0
• Genetic Background: involves: BALB/c * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to type I hypersensitivity reaction ( J:100568 )

• transgenic mice are more susceptible to passive systemic anaphylaxis

Genotype
MGI:3716474

tg2

• Allelic Composition: Tg(Pim1-Il9)5Jcrd/0
• Genetic Background: involves: FVB/N

immune system

increased T cell derived lymphoma incidence ( J:17848 )

• between 3 - 9 months of age, 14 of 200 transgenic mice developed tumors that appeared to arise from immature thymic T cells

increased susceptibility to type I hypersensitivity reaction ( J:100568 )

• transgenic mice are highly susceptible to passive systemic anaphylaxis and die within 30 minutes of a challenge with DNP coupled to BSA 1 day after an i.v. injection with 5 ug of monoclonal anti-DP IgE, while all wild-type mice survived

• however, transgenic mice are not more susceptible to passive cutaneous anaphylaxis

increased interleukin-5 secretion ( J:115764 )

• transgenic CD4+ T cells produce more Il-5 than wild-type cells in response to anti-CD3 stimulation; secretion is inhibited by neutralization of Il-9 by addition of an antibody to the culture

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:17848 )

• a dose of 1 ug of N-methyl-N-nitrosourea induced tumors in all transgenic mice but did not induce tumors in wild-type mice

neoplasm

increased T cell derived lymphoma incidence ( J:17848 )

• between 3 - 9 months of age, 14 of 200 transgenic mice developed tumors that appeared to arise from immature thymic T cells

increased incidence of tumors by chemical induction ( J:17848 )

• a dose of 1 ug of N-methyl-N-nitrosourea induced tumors in all transgenic mice but did not induce tumors in wild-type mice

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:17848 )

• between 3 - 9 months of age, 14 of 200 transgenic mice developed tumors that appeared to arise from immature thymic T cells

hematopoietic system

increased T cell derived lymphoma incidence ( J:17848 )

• between 3 - 9 months of age, 14 of 200 transgenic mice developed tumors that appeared to arise from immature thymic T cells