Phenotypes associated with this allele

• Allele Symbol: Tg(Eno2-PSEN1)1Gae
• Allele Name: transgene insertion 1, Gregory A Elder
• Allele ID: MGI:3590650
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Eno2-PSEN1)1Gae/0	involves: C57BL/6J * DBA/2J	MGI:3718122

Genotype
MGI:3718122

tg1

• Allelic Composition: Tg(Eno2-PSEN1)1Gae/0
• Genetic Background: involves: C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:100959 )

N • transgene expression has no effect on total granule cell number in the adult brain

abnormal neuron differentiation ( J:100959 )

• fractional survival of labeled neuronal precursors in the granule cell layer 4 weeks after BrdU injection is significantly higher than in wild-type; transgene expression promotes survival and differentiation of neuronal precursors relative to wild-type

decreased neuronal precursor cell number ( J:100959 )

• number of progenitor cells is decreased to 3614 compared to 6114 in non transgenic controls as detected by BrdU labeling in hippocampus of 2-month old animals

cellular

abnormal neuron differentiation ( J:100959 )

• fractional survival of labeled neuronal precursors in the granule cell layer 4 weeks after BrdU injection is significantly higher than in wild-type; transgene expression promotes survival and differentiation of neuronal precursors relative to wild-type