All Phenotypes Mapt<tm1(Ewsr1/Etv4)Arbr> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mapt^{tm1(Ewsr1/Etv4)Arbr}
targeted mutation 1, Silvia Arber
MGI:3590681

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Isl1^tm1(cre)Tmj/Isl1⁺ Mapt^{tm1(Ewsr1/Etv4)Arbr}/Mapt⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3716103
cn2	Mapt^{tm1(Ewsr1/Etv4)Arbr}/Mapt⁺ Mnx1^tm4(cre)Tmj/Mnx1⁺	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6	MGI:3716107

Allelic Composition	Isl1^tm1(cre)Tmj/Isl1⁺ Mapt^{tm1(Ewsr1/Etv4)Arbr}/Mapt⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1^tm1(cre)Tmj mutation (0 available); any Isl1 mutation (36 available)
Mapt^{tm1(Ewsr1/Etv4)Arbr} mutation (0 available); any Mapt mutation (430 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased muscle spindle number ( J:100886 )

• mice have 25% of the wild-type number of muscle spindles

abnormal sensory neuron morphology ( J:100886 )

• while sensory axons reach the skin only rudimentary sensory axon branching is established within the skin

abnormal sensory neuron innervation pattern ( J:100886 )

• sensory afferents fail to invade the spinal cord and are found in an extreme lateral position at the dorsal root entry zone

• sensory afferents are bifurcated at the entry point

• sensory afferent fibers fail to approach the midline at the distal segments and continue to occupy an extreme lateral position

abnormal dorsal root ganglion morphology ( J:100886 )

• unlike wild-type cells, dorsal root ganglia neurons survive in culture without the addition of neurotrophic agents

• whole dorsal root ganglia require neurotrophin-3 for survival

muscle

decreased muscle spindle number ( J:100886 )

• mice have 25% of the wild-type number of muscle spindles

Allelic Composition	Mapt^{tm1(Ewsr1/Etv4)Arbr}/Mapt⁺ Mnx1^tm4(cre)Tmj/Mnx1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapt^{tm1(Ewsr1/Etv4)Arbr} mutation (0 available); any Mapt mutation (430 available)
Mnx1^tm4(cre)Tmj mutation (2 available); any Mnx1 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon extension ( J:100886 )

• mice have very few dorsal root ganglia neurons at brachial levels and increasingly more neurons progressing caudally undergo recombination

cellular

abnormal axon extension ( J:100886 )

• mice have very few dorsal root ganglia neurons at brachial levels and increasingly more neurons progressing caudally undergo recombination

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24