All Phenotypes Pvalb<tm1(cre)Arbr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pvalb^tm1(cre)Arbr
targeted mutation 1, Silvia Arber
MGI:3590684

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Stk39^tm1Pawe/Stk39^tm1Pawe Pvalb^tm1(cre)Arbr/Pvalb⁺	B6.129-Stk39^tm1Pawe Pvalb^tm1(cre)Arbr	MGI:6423631
cn2	Erbb4^tm1Fej/Erbb4^tm1Fej Pvalb^tm1(cre)Arbr/Pvalb⁺	involves: 129 * C57BL/6	MGI:5318191
cn3	Adam23^tm1.1Mejr/Adam23^tm1.1Mejr Pvalb^tm1(cre)Arbr/Pvalb⁺	involves: 129P2/OlaHsd	MGI:7444419
cn4	Ctnnb1^tm2Kem/Ctnnb1^tm2Kem Pvalb^tm1(cre)Arbr/Pvalb⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5812797
cn5	Nlgn3^tm4.1Sud/Y Pvalb^tm1(cre)Arbr/Pvalb⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:5660863
cn6	Rem2^{tm1c(EUCOMM)Hmgu}/Rem2^{tm1c(EUCOMM)Hmgu} Pvalb^tm1(cre)Arbr/Pvalb⁺	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N	MGI:6192626
cn7	Celf2^tm1Yjin/Celf2^tm1Yjin Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Pvalb^tm1(cre)Arbr/Pvalb⁺	involves: 129P2/OlaHsd * 129S6/SvEvTac * BALB/c * C57BL/6NCrl	MGI:6307011
cn8	Gclc^tm1Tdal/Gclc^tm1Tdal Pvalb^tm1(cre)Arbr/Pvalb⁺	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6	MGI:5519058
cn9	Pvalb^tm1(cre)Arbr/Pvalb⁺ Slc12a6^tm2.1Dlp/Slc12a6^tm2.1Dlp	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J	MGI:5754621
cn10	Mapt^tm2Arbr/Mapt⁺ Pvalb^tm1(cre)Arbr/Pvalb⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3716104
cn11	Hprt1^{tm1(CAG-Glra3*)Jcme}/Y Pvalb^tm1(cre)Arbr/Pvalb⁺	involves: 129P2/OlaHsd * C57BL/6J	MGI:5608591
cn12	Lgi1^tm2.1Jkc/Lgi1^tm2.1Jkc Pvalb^tm1(cre)Arbr/0	involves: 129/Sv * 129P2/OlaHsd * C57BL/6	MGI:6275804

Allelic Composition	Stk39^tm1Pawe/Stk39^tm1Pawe Pvalb^tm1(cre)Arbr/Pvalb⁺
Genetic Background	B6.129-Stk39^tm1Pawe Pvalb^tm1(cre)Arbr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pvalb^tm1(cre)Arbr mutation (5 available); any Pvalb mutation (29 available)
Stk39^tm1Pawe mutation (0 available); any Stk39 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

hypertension ( J:287773 )

• higher systolic and diastolic blood pressure

• hypertension is especially pronounced during the active, awake period

• hydrochlorothiazide (HCTZ) treatment normalizes blood pressure

salt-sensitive hypertension ( J:287773 )

• dietary salt loading exacerbates hypertension

renal/urinary system

decreased urine potassium level ( J:287773 )

• mice exhibit lower rates of urinary potassium excretion and are unable to develop a transtubular potassium gradient, indicating impaired potassium secretion from the aldosterone-sensitive distal nephron

• HCTZ restores urinary potassium excretion and transtubular potassium gradient

abnormal nephron morphology ( J:287773 )

• aldosterone-sensitive distal nephron mass is reduced

• length and area of cortical distal nephron segment DCT1 is increased with a commensurate decrease in the length and area of the CNT segment

• HCTZ treatment reverses the structural nephron remodeling

abnormal kidney physiology ( J:287773 )

• salt-sensitive hypertension with low rein indicates aberrant gain in renal sodium absorption

hematopoietic system

decreased hematocrit ( J:287773 )

homeostasis/metabolism

decreased blood urea nitrogen level ( J:287773 )

• reduction in BUN levels

• HCTZ treatment corrects BUN levels

hyperkalemia ( J:287773 )

• mice exhibit high plasma potassium levels

• a potassium-rich diet exacerbates hyperkalemia

• HCTZ corrects the hyperkalemia

increased circulating chloride level ( J:287773 )

decreased urine potassium level ( J:287773 )

• HCTZ restores urinary potassium excretion and transtubular potassium gradient

metabolic acidosis ( J:287773 )

decreased renin activity ( J:287773 )

• plasma renin activity is decreased

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pseudohypoaldosteronism		DOID:4479		J:287773

Allelic Composition	Erbb4^tm1Fej/Erbb4^tm1Fej Pvalb^tm1(cre)Arbr/Pvalb⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb4^tm1Fej mutation (1 available); any Erbb4 mutation (87 available)
Pvalb^tm1(cre)Arbr mutation (5 available); any Pvalb mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:182690 )

N	• neither cued nor contextual fear conditioning are different from controls

increased locomotor activity ( J:182690 )

• animals exhibit significantly more locomoter activity than controls in open field test

nervous system

enhanced long-term potentiation ( J:182690 )

• significantly increased compared to controls (EPSC amplitude 322% vs 157%)

decreased prepulse inhibition ( J:182690 )

• animals display deficit in PPI; reductions in PPI are more pronounced at lower prepulse sound levels than in controls

• responses are similar to Erbb4^-/- mice

Allelic Composition	Adam23^tm1.1Mejr/Adam23^tm1.1Mejr Pvalb^tm1(cre)Arbr/Pvalb⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam23^tm1.1Mejr mutation (0 available); any Adam23 mutation (63 available)
Pvalb^tm1(cre)Arbr mutation (5 available); any Pvalb mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:333962 )

N	• mice exhibit normal peripheral axon myelination and Aalphabeta-fiber electrical threshold, amplitude, and conduction velocity

abnormal neuron morphology ( J:333962 )

• absent Kv1 channels complex accumulation at the juxtaparanodal membrane in neurons

abnormal neuron physiology ( J:333962 )

• application of 4-AP does not further prolong the refractory period in sensory root neurons unlike in wild-type mice

behavior/neurological

abnormal gait ( J:333962 )

• after 6 to 8 weeks

Allelic Composition	Ctnnb1^tm2Kem/Ctnnb1^tm2Kem Pvalb^tm1(cre)Arbr/Pvalb⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm2Kem mutation (1 available); any Ctnnb1 mutation (49 available)
Pvalb^tm1(cre)Arbr mutation (5 available); any Pvalb mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:236989 )

N	• mutants show normal behavior in the open field test, with no differences in total distance traveled, total time mobile, and total vertical rearing activity, normal behavior on the rotarod, and normal behavior in the tail suspension test, indicating that depression-related behavior is not affected

impaired long-term object recognition memory ( J:236989 )

• mutants show memory deficits in the novel object recognition test, with mutants showing no preference for novel object 2 when it replaced the familiar object 1 after 24 hours, indicating impaired long-term recognition memory

• however, short term memory is normal, with mutants interacting with a novel object similarly to controls after 1 hour

enhanced spatial learning ( J:236989 )

• mutants exhibit enhanced spatial memory in the Morris water maze; within 4 training days, mutants take less time and swim shorter distance to reach the platform, and show a higher percentage of successful rate of finding the hidden-platform within 60 seconds

• mutants show decreased travel distance, longer duration, and greater travel frequency into the platform quadrant after the platform is removed

• in a three-zone assessment with concentric circles of different diameters surrounding the platform, mutants show better navigation to the target, have shorter latencies to reach the smallest target zone, spend longer time, and enter more in the target zones, indicating that mutants can memorize the position of the platform in relation to spatial cues with higher accuracy

increased anxiety-related response ( J:236989 )

• in the marble burying test, mutants take more time to start to bury the marbles, however the final number of buried marbles is not different from controls, indicating that mutants dig more frequently in a shorter active period

increased thigmotaxis ( J:236989 )

• in the open field test, mice have less center distance traveled with similar velocities, and show less center entry and a longer latency to enter the center region, indicating increased anxiety

• in the 5-min open field test, mice spend less time in the center region

• in the elevated plus maze, mutants enter the closed arms much earlier than controls and take longer to enter the open arms, they prefer the closed arms more often than the open arms, they enter the closed arms more frequently than controls, and the distance they travel in the open arm is much less than in controls

• mutants are reluctant to enter the distal half of the open arms of the elevated plus maze

slow extinction of fear memory ( J:236989 )

• in the contextual fear conditioning freezer test, mutants do not decrease the percentage of freezing at the third day of extinction tests, indicating the memory extinction is impaired

• however, no differences were seen in the contextual fear conditioning test during the first 2 days, suggesting intact fear memory

abnormal response to social novelty ( J:236989 )

• mutants fail to show social novelty behavior in the social interaction test session when an unfamiliar mouse is introduced in the empty chamber

increased grooming behavior ( J:236989 )

• mutants spend more time grooming than controls

abnormal head movements ( J:236989 )

• mutants exhibit increased head-dipping behavior, especially at the center region of the plus maze apparatus, indicating compulsive-like behavior

stereotypic behavior ( J:236989 )

• mutants exhibit increased head-dipping behavior, especially at the center region of the plus maze apparatus, indicating compulsive-like behavior

abnormal nest building behavior ( J:236989 )

• mutants perform worse on nest building test than controls

nervous system

abnormal neuron physiology ( J:236989 )

• neuronal activation is reduced in the cortex, but not in the amygdala or hippocampus regions

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:236989

Allelic Composition	Nlgn3^tm4.1Sud/Y Pvalb^tm1(cre)Arbr/Pvalb⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3^tm4.1Sud mutation (0 available); any Nlgn3 mutation (36 available)
Pvalb^tm1(cre)Arbr mutation (5 available); any Pvalb mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased locomotor activity ( J:214636 )

• mice exhibit decreased activity in the open field

• however, performance on the rotarod is normal

Allelic Composition	Rem2^{tm1c(EUCOMM)Hmgu}/Rem2^{tm1c(EUCOMM)Hmgu} Pvalb^tm1(cre)Arbr/Pvalb⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pvalb^tm1(cre)Arbr mutation (5 available); any Pvalb mutation (29 available)
Rem2^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Rem2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:263600 )

N	• mice subjected to monocular deprivation exhibit normal ocular dominance plasticity

Allelic Composition	Celf2^tm1Yjin/Celf2^tm1Yjin Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Pvalb^tm1(cre)Arbr/Pvalb⁺
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * BALB/c * C57BL/6NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celf2^tm1Yjin mutation (0 available); any Celf2 mutation (44 available)
Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze} mutation (5 available); any Gt(ROSA)26Sor mutation (993 available)
Pvalb^tm1(cre)Arbr mutation (5 available); any Pvalb mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron physiology ( J:269731 )

• reduced adult dorsal root ganglia regeneration following sciatic nerve crush injury

Allelic Composition	Gclc^tm1Tdal/Gclc^tm1Tdal Pvalb^tm1(cre)Arbr/Pvalb⁺
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gclc^tm1Tdal mutation (0 available); any Gclc mutation (20 available)
Pvalb^tm1(cre)Arbr mutation (5 available); any Pvalb mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cingulate gyrus morphology ( J:197430 )

• significantly fewer parvalbumin labeled cells in the anterior cingulate cortex

• reduction of the aggrecan-enriched perineuronal nets

Allelic Composition	Pvalb^tm1(cre)Arbr/Pvalb⁺ Slc12a6^tm2.1Dlp/Slc12a6^tm2.1Dlp
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pvalb^tm1(cre)Arbr mutation (5 available); any Pvalb mutation (29 available)
Slc12a6^tm2.1Dlp mutation (0 available); any Slc12a6 mutation (120 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired coordination ( J:217087 )

• in the accelerated rotarod test, mice fall significantly faster than control mice (<150 sec versus >250 sec, respectively) but are able to improve their performance

• however, no significant difference in locomotor activity is noted in the open field test, despite a trend towards hyperactivity

nervous system

abnormal dorsal root ganglion morphology ( J:217087 )

• in the spinal cord, dorsal root ganglia exhibit large vacuoles as well as many structures containing dense material that is parvalbumin immunoreactive

Allelic Composition	Mapt^tm2Arbr/Mapt⁺ Pvalb^tm1(cre)Arbr/Pvalb⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapt^tm2Arbr mutation (1 available); any Mapt mutation (430 available)
Pvalb^tm1(cre)Arbr mutation (5 available); any Pvalb mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal dorsal root ganglion morphology ( J:100886 )

• whole dorsal root ganglia require neurotrophin-3 for survival

Allelic Composition	Hprt1^{tm1(CAG-Glra3*)Jcme}/Y Pvalb^tm1(cre)Arbr/Pvalb⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^{tm1(CAG-Glra3*)Jcme} mutation (0 available); any Hprt1 mutation (1279 available)
Pvalb^tm1(cre)Arbr mutation (5 available); any Pvalb mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal nervous system electrophysiology ( J:207981 )

• amplitudes of evoked field potentials are reduced in CA1 slices

• the power of gamma oscillations in hippocampal subfield CA1 is reduced

• require a higher concentration of bicuculline methiodide to induce pathological activity

abnormal CNS synaptic transmission ( J:207981 )

• bidirectional synaptic plasticity is compromised

absent long-term depression ( J:207981 )

• could not be elicited

behavior/neurological

behavior/neurological phenotype ( J:207981 )

N	• performance is similar to controls in discriminative associative learning and memory tests

increased anxiety-related response ( J:207981 )

• in light/dark preference, open field and elevated plus maze tests

Allelic Composition	Lgi1^tm2.1Jkc/Lgi1^tm2.1Jkc Pvalb^tm1(cre)Arbr/0
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgi1^tm2.1Jkc mutation (1 available); any Lgi1 mutation (33 available)
Pvalb^tm1(cre)Arbr mutation (5 available); any Pvalb mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:269784 )

N	• mice do not develop seizures, cortical dysplasia or hypercellularity in the outer cortical layers

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