Phenotypes associated with this allele

• Allele Symbol: nmf419
• Allele Name: neuroscience mutagenesis facility, 419
• Allele ID: MGI:3603001
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	nmf419/nmf419	B6;CByJ-nmf419/J	MGI:3603002

Genotype
MGI:3603002

hm1

• Allelic Composition: nmf419/nmf419
• Genetic Background: B6;CByJ-nmf419/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:82238 )

N • mutant mice exhibit a brisk hind limb withdrawal (flexor) reflex when a rear leg is tugged gently

limb grasping ( J:82238 )

• when lifed by their tails, wean-age mutant mice draw their hind limbs close to their bodies

tremors ( J:82238 )

• at weaning (age 4.3 +/- 1.7 weeks), mutant mice exhibit movement-associated tremors

paraparesis ( J:82238 )

• the hindquarters of wean-age mutant mice remain low during locomotion, suggesting weakness of the hind limbs

nervous system

peripheral nervous system degeneration ( J:82238 )

• upon standard pathology examination, two of three mutant mice aged 22-33 days were found to have mild nerve degeneration in their hindlimbs