Analysis Tools
mortality/aging
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• die by 30 weeks of age due to gastrointestinal obstruction by hyperplastic interstitial cells of Cajal or gastrointestinal stromal tumors
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cellular
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• ovaries are devoid of germ cells
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azoospermia
(
J:100778
)
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• mature spermatids or spermatozoa are absent
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pigmentation
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• have uniform white coats with normally pigmented dark brown eyes
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hematopoietic system
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• decrease in dermal mast cells
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immune system
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• decrease in dermal mast cells
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neoplasm
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• develop gastrointestinal stromal tumors (GIST) that are composed of a dense, cellular proliferation of monomorphic spindle cells
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reproductive system
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• ovaries are devoid of germ cells
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azoospermia
(
J:100778
)
|
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• mature spermatids or spermatozoa are absent
|
|
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• ovaries consist of stromal cells that range from spindle shaped to more rounded inhibin-positive/Kit-negative luteinized cells
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small ovary
(
J:100778
)
|
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|
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• seminiferous tubules contain only one layer of primary germ cells and no spermatids and contain abundant, pale, eosinophilic, flocculent secretions
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|
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• progressive Leydig cell hyperplasia as mice age
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digestive/alimentary system
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• interstitial cells of Cajal (ICC) hyperplasia in the esophagus, stomach, proximal duodenum, and the colon/rectum
• ICC is first apparent within the myenterci plexus, grows asymmetrically and is most prominent in the pylorus, where it completely effaces the muscular wall and extends through the muscularis mucosae to engulf the mucosa
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• ceca are abnormally firm and contain tumors
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• subset of mice develop mega-ileum due to gastrointestinal tract obstruction at the cecum
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• develop gastrointestinal stromal tumors (GIST) that are composed of a dense, cellular proliferation of monomorphic spindle cells
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• intestinal obstruction at the pylorus or the cecum is seen shortly after weaning and leads to death
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growth/size/body
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• within 3 weeks of birth, a subset of mice develop distended abdomens due to gastrointestinal tract obstruction at the pylorus
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endocrine/exocrine glands
|
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• ovaries consist of stromal cells that range from spindle shaped to more rounded inhibin-positive/Kit-negative luteinized cells
|
small ovary
(
J:100778
)
|
|
|
|
|
• seminiferous tubules contain only one layer of primary germ cells and no spermatids and contain abundant, pale, eosinophilic, flocculent secretions
|
|
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• progressive Leydig cell hyperplasia as mice age
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integument
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• have uniform white coats with normally pigmented dark brown eyes
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| gastrointestinal stromal tumor | DOID:9253 |
OMIM:606764 |
J:100778 | |
