Analysis Tools|
Allele Symbol Allele Name Allele ID |
Sil1Gt(RST462)Byg gene trap RST462, BayGenomics MGI:3603007 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 10 weeks, Purkinje cells accumulate ubiquitin+ inclusions, a marker of endoplasmic reticulum stress
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• at 20 weeks, mice exhibit a wide stance compared with wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• exhibit the same phenotype and pathology as homozygous Sil1wz mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• exhibit the same phenotype and pathology as homozygous Sil1wz mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• after 4 months
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 6 to 8 weeks, Purkinje cells accumulate ubiquitin+ inclusions, a marker of endoplasmic reticulum stress
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• at 4 and 6 weeks, Purkinje cells exhibit degeneration
• by 20 weeks most Purkinje cells have degenerated
• unlike Sil1Gt(RST462)Byg homozygotes, Purkinje cells in lobule X and caudal lobule IX degenerate by 3 months of age
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• at 10 weeks, mice exhibit a wide stance compared with wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• at 20 weeks, mice exhibit a normal rear stance width unlike Sil1Gt(RST462)Byg homozygotes
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• at 4 months of age, mice begin to exhibit Purkinje cell degeneration
• however, by 8 months most Purkinje cells remain intact and few Purkinje cells exhibit ubiquitin+ inclusions
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• unlike Sil1Gt(RST462)Byg homozygotes, mice do not exhibit ataxia
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| N |
• unlike Sil1Gt(RST462)Byg homozygotes, mice up to 8 months of age do not exhibit Purkinje cell degeneration
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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