Phenotypes associated with this allele

• Allele Symbol: Lbx1^tm2Cbm
• Allele Name: targeted mutation 2, Carmen Birchmeier
• Allele ID: MGI:3603145
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Lbx1^tm2Cbm/Lbx1^tm3.1(cre)Cbm Mapt^tm2Arbr/Mapt^+	involves: 129P2/OlaHsd	MGI:3710960

Genotype
MGI:3710960

cn1

• Allelic Composition: Lbx1^tm2Cbm/Lbx1^{tm3.1(cre)Cbm}; Mapt^tm2Arbr/Mapt⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brainstem morphology ( J:121332 )

• spinal trigeminal nucleus (SpV, trigeminal somatosensory relay nucleus) does not form; Lmx1b+ and Tlx3+ neurons cannot be detected at E14 and 18 in lateral medulla, but such neurons ar abundant in control SpV

abnormal medulla oblongata morphology ( J:121332 )

• ectopic dB3* and dBLb3* neurons are assembled in a broad dorsal band

• absence of SpV causes shape abnormalities in medulla

abnormal neuron morphology ( J:121332 )

• mutants have increased number of tyrosine hydroxylase-positive neurons in dorsal medulla

abnormal neuron differentiation ( J:121332 )

• many ectopic neurons are observed in the ventral alar plate at E10.5

• neurons expressing Phox2b, Lmx1b, and Tlx3, thus diplaying identity of dA3 neurons, arise early in neurogenesis at positions where dB3 neurons are normally generated, and are designated dB3* neurons

• such ectopic neurons (DBLb*) also arise during the late phase of neurogenesis, at the expense of dBLb (late-born dB neurons) whereas Phox2b+ neurons are only generated early in control mice

increased sensory neuron number ( J:121332 )

abnormal neuron specification ( J:121332 )

• dB3 and dBLb neurons are misspecified, and an increased number of ectopic dB3* and dBLb3* neurons with the molecular characteristics of dA3 neurons Lmx1b are seen in mutants vs controls at E14 and settle like dA3 neurons in a broad band in dorsal medulla close to solitary tract

cellular

abnormal neuron differentiation ( J:121332 )

• many ectopic neurons are observed in the ventral alar plate at E10.5

• neurons expressing Phox2b, Lmx1b, and Tlx3, thus diplaying identity of dA3 neurons, arise early in neurogenesis at positions where dB3 neurons are normally generated, and are designated dB3* neurons

• such ectopic neurons (DBLb*) also arise during the late phase of neurogenesis, at the expense of dBLb (late-born dB neurons) whereas Phox2b+ neurons are only generated early in control mice