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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnfrsf12atm1Biib
targeted mutation 1, Biogen Idec
MGI:3603146
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tnfrsf12atm1Biib/Tnfrsf12atm1Biib B6.129S4-Tnfrsf12atm1Biib MGI:3604220


Genotype
MGI:3604220
hm1
Allelic
Composition		 Tnfrsf12atm1Biib/Tnfrsf12atm1Biib
Genetic
Background		 B6.129S4-Tnfrsf12atm1Biib
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf12atm1Biib mutation (0 available); any Tnfrsf12a mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
abnormal oval cell physiology ( J:100907 )
• following chemically induced liver injury using 3,5-diethoxycarbonyl-1,4-dihydroxycollidine or injection with an adenovirus Tnfsf12 hyperproliferation of oval cells is reduced by 40% or absent, respectively

immune system
abnormal chemokine secretion ( J:126416 )
• mesangial cells fail to secrete the chemokine CXCL10 when cultured with Tnfrs12 (TWEAK) factor




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory