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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rps6tm1Om
targeted mutation 1, Oded Meyuhas
MGI:3603166
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rps6tm1Om/Rps6tm1Om involves: 129S1/Sv * 129X1/SvJ * ICR MGI:3608055


Genotype
MGI:3608055
hm1
Allelic
Composition
Rps6tm1Om/Rps6tm1Om
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps6tm1Om mutation (0 available); any Rps6 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• MEFs are 24% smaller than in wild-type due to impaired growth but not accelerated cell division
• MEFs accumulate proteins 1.4-fold faster than in wild-type, have a significantly shorter population doubling time, and exhibit a 14% decrease in the half-transit time of ribosomes
• decrease in the percentage of MEFs in G1 phase, reflecting a shortening of G1 from 16.4 hours in wild-type to 8.2 hours in mutant MEFs

endocrine/exocrine glands
• greater density of cells in islets
• beta cells are reduced in size, however total beta cell mass is similar to wild-type and acinar cells and T lymphocytes are normal size
• 2-fold decrease in total pancreatic insulin content

homeostasis/metabolism
• 2-fold decrease in total pancreatic insulin content
• 2-fold reduction in insulin levels during a fasting state
• exhibit a higher and prolonged hyperglycemic response following glucose challenge
• increased insulin sensitivity in peripheral tissues

liver/biliary system
• IL-7 dependent cells from E14 livers are 19% smaller than in wild-type, however newborn weight is normal





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory