Phenotypes associated with this allele

• Allele Symbol: Thrb^tm5Few
• Allele Name: targeted mutation 5, Fredric E Wondisford
• Allele ID: MGI:3603187
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Thrb^tm5Few/Thrb^tm5Few	involves: 129 * C57BL/6	MGI:3608672
ht2	Thrb^tm5Few/Thrb^+	involves: 129 * C57BL/6	MGI:3608673

Genotype
MGI:3608672

hm1

• Allelic Composition: Thrb^tm5Few/Thrb^tm5Few
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating thyroid-stimulating hormone level ( J:100929 )

• basal thyroid-stimulating hormone levels are increased

increased circulating thyroxine level ( J:100929 )

• T4 levels are increased up to 5-fold compared to wild-type mice and despite increased T3 and T4 levels RNA expression of thyroid-stimulating hormone and Tshb in the serum and Gsta RNA expression in the liver are not suppressed

increased circulating triiodothyronine level ( J:100929 )

• T3 levels are increased up to 5-fold compared to wild-type mice and despite increased T3 and T4 levels RNA expression of thyroid-stimulating hormone and Tshb in the serum and Gsta RNA expression in the liver are not suppressed

endocrine/exocrine glands

increased thyroid gland weight ( J:100929 )

• thyroid weight is increased about 3-fold compared to wild-type mice

Genotype
MGI:3608673

ht2

• Allelic Composition: Thrb^tm5Few/Thrb⁺
• Genetic Background: involves: 129 * C57BL/6

homeostasis/metabolism

increased circulating thyroxine level ( J:100929 )

• T4 levels are increased about 2-fold compared to wild-type mice

endocrine/exocrine glands

increased thyroid gland weight ( J:100929 )

• thyroid weight is increased compared to wild-type mice but not as much as in homozygous mice