Phenotypes associated with this allele

• Allele Symbol: Socs7^tm1Pbro
• Allele Name: targeted mutation 1, Paul B Rothman
• Allele ID: MGI:3603205
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Socs7^tm1Pbro/Socs7^tm1Pbro	B6.129S1-Socs7^tm1Pbro	MGI:3605048
hm2	Socs7^tm1Pbro/Socs7^tm1Pbro	involves: 129S1/Sv * C57BL/6	MGI:3605049

Genotype
MGI:3605048

hm1

• Allelic Composition: Socs7^tm1Pbro/Socs7^tm1Pbro
• Genetic Background: B6.129S1-Socs7^tm1Pbro

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:100915 )

• homozygous mutant mice are born at the predicted Mendelian frequency but display multiple defects at an early age and die postnatally

nervous system

hydrocephaly ( J:100915 )

• seen in more than 50% of mice

growth/size/body

postnatal growth retardation ( J:100915 )

• seen in more than 50% of mice

homeostasis/metabolism

hypoglycemia ( J:100915 )

• seen in more than 50% of mice

Genotype
MGI:3605049

hm2

• Allelic Composition: Socs7^tm1Pbro/Socs7^tm1Pbro
• Genetic Background: involves: 129S1/Sv * C57BL/6

mortality/aging

mortality/aging ( J:100915 )

N • in mixed background, mutant mice were identical in length, weight, and body composition to wild-type littermates at up to 6 months of age

homeostasis/metabolism

abnormal glucose homeostasis ( J:100915 )

• lower blood glucose and higher plasma insulin concentration in over-night-fasted mice aged at least 6 months compared to wild-type control

improved glucose tolerance ( J:100915 )

increased insulin sensitivity ( J:100915 )