Analysis Tools|
Allele Symbol Allele Name Allele ID |
Thratm3Ven targeted mutation 3, Bjorn Vennstrom MGI:3603303 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygous mutants died within 2 weeks after birth
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• homozygous mutants exhibited lower body weight at 10 days after birth
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• heterozygous mutants exhibited lower body weight at 10 days after birth and a difference increased to 33% at 30 days of age compared with wt controls
• 90-day-old heterozygous mice weighed only 7% less than wt controls
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• eye opening, bone ossification and development of IgM-positive B cells are delayed by 5-10 days in the juvenile mice
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• using the novel object recognition task to measure visual recognition memory, mutant 12-14-wk-old mice displayed a memory impairment
• administration of T3 in drinking water during adulthood restored normal recognition memory
• administration of TS during juveniles failed to correct the memory impairment
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• 12-14-wk-old mutant mice exhibited a reduced exploratory activity in a brightly lit open field
• 12-14-wk-old mutant mice exhibited a pronounced tendency for retropulsion and a strongly increased freezing behavior
• 12-14-wk-old mutant exhibited increased anxiety-like behavior in the elevated plus maze
• administration of T3 in drinking water during adulthood abolished the abnormal exploratory activity and anxiety but not freezing behavior
• administration of T3 during P10-P35 failed to ameliorate abnormal exploratory and anxiety behaviors
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• 12-14-wk-old mutant male animals had significantly reduced locomotor coordination on rotarod test
• administration of T3 and T4 during P10-P35 fully restored locomotor ability
• administration of T3 in drinking water during adulthood failed to enhance the locomotor ability
• no difference was seen between wild-type and mutant female mice
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• the mutant mice had a delay of 4-6 days in the post-natal migration of cerebellar external granular cells to the internal granular layer
• no obvious abnormalities were found among adult mutant cerebellum by histological analyses
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• mutant mice displayed a 40-50% reduction in the number of parvalbumin (PV)-positive cell bodies that was resulted from a reduction in the number of the subpopulation of GABAergic interneurons
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• compound heterozygous mutants exhibited 35% less body weight at 35 days of age compared with simple heterozygous Thratm1Ven/Thra+ controls
• 70-day-old heterozygous mice weighed only 16% less than simple heterozygous Thratm1Ven/Thra+ controls
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• delayed eye opening
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• compound heterozygous mutants exhibited 27% less body weight at 30 days of age compared with simple heterozygous Thratm2Ven/Thra+ controls
• 70-day-old compound heterozygous mice weighed only 5% less than simple heterozygous Thratm2Ven/Thra+ controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• double homozygous mutant class was not found in intercross between double heterozygote Thratm3Ven/Thra+
Thrbtm1Df/Thrb+ indicating lethality
• actual time of death has not been determined
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• male Thratm3Ven/Thra+ Thrbtm1Df/Thrb+ mutants exhibited 40% less body weight at 31 days of age compared with Thra+/Thra+ Thrbtm1Df/Thrb+ controls
• similar results were obtained with female mice, although the growth retardation of Thratm3Ven/Thra+ Thrbtm1Df/Thrb+ mutants was less at 22%
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• the delay in eye opening was partially rescued, occurring at day 15.3 in the Thratm3Ven/Thra+ Thrbtm1Df/Thrb+ mutants compared with day 18.6 in the Thra+/Thra+ Thrbtm1Df/Thrb+, and day 14 in the wt mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• male Thratm3Ven/Thra+ Thrbtm1Df/Thrbtm1Df mutants exhibited only 14% less body weight at 31 days of age compared with controls
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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