Phenotypes associated with this allele

• Allele Symbol: Fhl2^tm2Wlm
• Allele Name: targeted mutation 2, R Sanders Williams
• Allele ID: MGI:3603305
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fhl2^tm2Wlm/Fhl2^tm2Wlm	B6.Cg-Fhl2^tm2Wlm	MGI:3607181
hm2	Fhl2^tm2Wlm/Fhl2^tm2Wlm	Not Specified	MGI:3606734

Genotype
MGI:3607181

hm1

• Allelic Composition: Fhl2^tm2Wlm/Fhl2^tm2Wlm
• Genetic Background: B6.Cg-Fhl2^tm2Wlm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

decreased bone mineral density ( J:100765 )

• osteopenia

decreased bone mass ( J:100765 )

• mutant mice bone mass is progressively lost over 1week to 9 months of age analyzed

• 9 month old mutant mice show a marked reduction in bone mass by 32% compared to age-and sex-matched wild-type control animals

osteoporosis ( J:100765 )

• number of osteoblasts and osteoclasts relative to the bone volume was not altered

• osteoclast activity is not affected

• the bone formation rate is reduced by 24% in mutant mice

Genotype
MGI:3606734

hm2

• Allelic Composition: Fhl2^tm2Wlm/Fhl2^tm2Wlm
• Genetic Background: Not Specified

cardiovascular system

cardiac hypertrophy ( J:100289 )

• cardiac hypertrophy induced by administration of isoproterenol was exaggerated above that in wild-type animals

• in the absence of drug treatment, there was no apparent difference in heart-weight/body-weight ratios among mutant mice compared with wild-type controls

growth/size/body

cardiac hypertrophy ( J:100289 )

• cardiac hypertrophy induced by administration of isoproterenol was exaggerated above that in wild-type animals

• in the absence of drug treatment, there was no apparent difference in heart-weight/body-weight ratios among mutant mice compared with wild-type controls