Phenotypes associated with this allele

• Allele Symbol: Prkca^tm1Cda
• Allele Name: targeted mutation 1, Kazuhiro Chida
• Allele ID: MGI:3603307
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prkca^tm1Cda/Prkca^tm1Cda	involves: 129S/SvEv * C57BL/6	MGI:3606732

Genotype
MGI:3606732

hm1

• Allelic Composition: Prkca^tm1Cda/Prkca^tm1Cda
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased skin papilloma incidence ( J:100793 )

• incidence of papilloma formation was increased in mutant mice by two-stage skin carcinogenesis in which DMBA was used as an initiator and TPA as a promoter

integument

epidermal hyperplasia ( J:100793 )

• epidermal hyperplasia induced by a single topical application of TPA was markedly reduced

• topical TPA treatment increased Brdu labeled basal keratinocytes at 16 to 24 hours but significantly decreased at 36 and 48 hours after application

• epidermal hyperplasia induced by skin wound showed a thinner regenerating epidermis

increased skin papilloma incidence ( J:100793 )

• incidence of papilloma formation was increased in mutant mice by two-stage skin carcinogenesis in which DMBA was used as an initiator and TPA as a promoter