Phenotypes associated with this allele

• Allele Symbol: Pdx1^tm1Heed
• Allele Name: targeted mutation 1, Helena Edlund
• Allele ID: MGI:3603310
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pdx1^tm1Heed/Pdx1^tm1Heed Tg(Ins2-cre)1Heed/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3603658

Genotype
MGI:3603658

cn1

• Allelic Composition: Pdx1^tm1Heed/Pdx1^tm1Heed; Tg(Ins2-cre)1Heed/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:48516 )

• about 22% of islet cells coexpress insulin and glucagon

increased pancreatic alpha cell number ( J:48516 )

• the number of glucagon+ cells is increased to 33% compared to 15% in wild-type mice resulting in about a 1:1 ratio of insulin+ to glucagon+ cells rather than the normal 5:1 ratio

decreased pancreatic beta cell number ( J:48516 )

• at 18 weeks of age the number of insulin+ cells is reduced by about 40% and only 17% of these cells coexpress IPF1

disorganized pancreatic islets ( J:48516 )

• glucagon+ cells are more evenly distributed within the islet rather than being confined to the periphery as in wild-type mice

abnormal pancreatic beta cell physiology ( J:48516 )

• pancreatic total insulin content is about 10% that of wild-type

homeostasis/metabolism

increased circulating glucose level ( J:48516 )

• at 3 - 5 months of age blood glucose levels are significantly elevated

• insulin treatment transiently reduced glucose levels to normal levels

increased urine glucose level ( J:48516 )

• at 3 - 5 months of age urine glucose levels are significantly elevated

renal/urinary system

increased urine glucose level ( J:48516 )

• at 3 - 5 months of age urine glucose levels are significantly elevated