Phenotypes associated with this allele

• Allele Symbol: Syngap1^tm1.2Mabk
• Allele Name: targeted mutation 1.2, Mary B Kennedy
• Allele ID: MGI:3603311
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Syngap1^tm1.1Mabk/Syngap1^tm1.2Mabk Tg(Camk2a-cre)2834Lusc/0	involves: 129S1/Sv * C57BL/6	MGI:3604393

Genotype
MGI:3604393

cn1

• Allelic Composition: Syngap1^tm1.1Mabk/Syngap1^tm1.2Mabk; Tg(Camk2a-cre)2834Lusc/0
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:101084 )

• 12.6% (13 out of 103) referred to as "mini" were significantly smaller at P7 and died by 3 weeks after birth

• remaining mutant were phenotypically normal up to the forth postnatal week and their weight was statistically indistinguishable from controls

nervous system

increased neuron apoptosis ( J:101084 )

• many more neurons stain positively for activated caspase-3 in the brains of homozygous mice at 2 weeks and 8weeks after birth

• more activation of caspase-3 in the cell body layers of the hippocampus were found note: level of synGAP protein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group more activation of caspase-3 in the cell body layerof the hippocampus were found note: level of synGAP protein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group more activation of caspase-3 in the cell body layers of the hippocampus were found note: level of synGAProtein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group more activation of caspase-3 in the cell body layers of the hippocampus were found

• level of synGAP protein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group

• level of synGAP protein correlate with severity of neuronal apoptosis

cellular

increased neuron apoptosis ( J:101084 )

• many more neurons stain positively for activated caspase-3 in the brains of homozygous mice at 2 weeks and 8weeks after birth

• more activation of caspase-3 in the cell body layers of the hippocampus were found note: level of synGAP protein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group more activation of caspase-3 in the cell body layerof the hippocampus were found note: level of synGAP protein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group more activation of caspase-3 in the cell body layers of the hippocampus were found note: level of synGAProtein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group more activation of caspase-3 in the cell body layers of the hippocampus were found

• level of synGAP protein correspond to 20-25% of wild-type in ""mini"" group and 37.5% of wild-type in normal group

• level of synGAP protein correlate with severity of neuronal apoptosis