Phenotypes associated with this allele

• Allele Symbol: Casp7^tm1Flv
• Allele Name: targeted mutation 1, Richard A Flavell
• Allele ID: MGI:3603317
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Casp7^tm1Flv/Casp7^tm1Flv	B6.129S6-Casp7^tm1Flv	MGI:3810972
hm2	Casp7^tm1Flv/Casp7^tm1Flv	Not Specified	MGI:3603540
cx3	Casp3^tm1Flv/Casp3^tm1Flv Casp7^tm1Flv/Casp7^+	B6.129S-Casp3^tm1Flv Casp7^tm1Flv	MGI:3810970
cx4	Casp3^tm1Flv/Casp3^tm1Flv Casp7^tm1Flv/Casp7^tm1Flv	B6.129S-Casp3^tm1Flv Casp7^tm1Flv	MGI:3810971

Genotype
MGI:3810972

hm1

• Allelic Composition: Casp7^tm1Flv/Casp7^tm1Flv
• Genetic Background: B6.129S6-Casp7^tm1Flv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased fibroblast apoptosis ( J:105496 )

• mouse embryonic fibroblasts (MEFs) exhibit a slight decrease in apoptosis rates following exposure to various insults

• following UV irradiation and staurosporine treatment, MEFs exhibit increased survival compared to wild type or Casp7^tm1Flv MEFs

immune system

immune system phenotype ( J:105496 )

N • lymphoid development and T cell apoptosis are normal

Genotype
MGI:3603540

hm2

• Allelic Composition: Casp7^tm1Flv/Casp7^tm1Flv
• Genetic Background: Not Specified

vision/eye

vision/eye phenotype ( J:101037 )

N • lenses appear grossly normal

N • lens extracts display normal levels of lysis of fluorogenic substrate DEVD-AMC

Genotype
MGI:3810970

cx3

• Allelic Composition: Casp3^tm1Flv/Casp3^tm1Flv; Casp7^tm1Flv/Casp7⁺
• Genetic Background: B6.129S-Casp3^tm1Flv Casp7^tm1Flv

cellular

decreased sensitivity to induced cell death ( J:105496 )

• mouse embryonic fibroblasts (MEFs) subjected to UV irradiation and staurosporine exhibit distorted chromosome condensation and nuclear fragmentation is absent unlike in similarly treated MEFs

decreased thymocyte apoptosis ( J:105496 )

• following injection of fetal liver cells into a RAG-deficient background, thymocyte apoptosis induced by mitochondrial pathways is decreased although not as much as in Casp3^tm1Flv Casp7^tm1Flv homozygous T cells

decreased fibroblast apoptosis ( J:105496 )

• apoptosis is decreased in mouse embryonic fibroblasts (MEFs) subjected to UV irradiation and staurosporine comapred to in wild-type MEFs

• MEFs exhibit decreased apoptosis following stimulation of the death receptor pathway that is intermediate to the response observed in Casp3^tm1Flv Casp7^tm1Flv homozygous MEFs

immune system

decreased thymocyte apoptosis ( J:105496 )

• following injection of fetal liver cells into a RAG-deficient background, thymocyte apoptosis induced by mitochondrial pathways is decreased although not as much as in Casp3^tm1Flv Casp7^tm1Flv homozygous T cells

hematopoietic system

decreased thymocyte apoptosis ( J:105496 )

• following injection of fetal liver cells into a RAG-deficient background, thymocyte apoptosis induced by mitochondrial pathways is decreased although not as much as in Casp3^tm1Flv Casp7^tm1Flv homozygous T cells

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:105496 )

• following injection of fetal liver cells into a RAG-deficient background, thymocyte apoptosis induced by mitochondrial pathways is decreased although not as much as in Casp3^tm1Flv Casp7^tm1Flv homozygous T cells

Genotype
MGI:3810971

cx4

• Allelic Composition: Casp3^tm1Flv/Casp3^tm1Flv; Casp7^tm1Flv/Casp7^tm1Flv
• Genetic Background: B6.129S-Casp3^tm1Flv Casp7^tm1Flv

mortality/aging

postnatal lethality, complete penetrance ( J:105496 )

• mice die rapidly after birth and by P10 to P14 no mice are alive

neonatal lethality, incomplete penetrance ( J:105496 )

• though present in Mendelian ratios at E20, mice die rapidly after birth

cellular

decreased sensitivity to induced cell death ( J:105496 )

• mouse embryonic fibroblasts (MEFs) subjected to UV irradiation and staurosporine fail to exhibit evidence of normal apoptosis 24hrs after treatment unlike in wild type MEFs

decreased thymocyte apoptosis ( J:105496 )

• following injection of fetal liver cells into a RAG-deficient background, thymocyte apoptosis induced by mitochondrial pathways is decreased

• however, thymocytes are still sensitive to death receptor mediated apoptosis

decreased fibroblast apoptosis ( J:105496 )

• mouse embryonic fibroblasts (MEFs) subjected to UV irradiation and staurosporine fail to undergo apoptosis

• MEFs exhibit decreased apoptosis following stimulation of the death receptor pathway

• following induction of apoptosis, MEFs fail to exhibit a loss of mitochondrial membrane potential

cardiovascular system

dilated heart atrium ( J:105496 )

• at E20

abnormal heart ventricle morphology ( J:105496 )

• at E20, the ventricular wall is disorganized and noncompacted

nervous system

exencephaly ( J:105496 )

• in 10% of mice

immune system

decreased thymocyte apoptosis ( J:105496 )

• following injection of fetal liver cells into a RAG-deficient background, thymocyte apoptosis induced by mitochondrial pathways is decreased

• however, thymocytes are still sensitive to death receptor mediated apoptosis

hematopoietic system

decreased thymocyte apoptosis ( J:105496 )

• following injection of fetal liver cells into a RAG-deficient background, thymocyte apoptosis induced by mitochondrial pathways is decreased

• however, thymocytes are still sensitive to death receptor mediated apoptosis

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:105496 )

• following injection of fetal liver cells into a RAG-deficient background, thymocyte apoptosis induced by mitochondrial pathways is decreased

• however, thymocytes are still sensitive to death receptor mediated apoptosis