Phenotypes associated with this allele

• Allele Symbol: Casp6^tm1Flv
• Allele Name: targeted mutation 1, Richard A Flavell
• Allele ID: MGI:3603318
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Casp6^tm1Flv/Casp6^tm1Flv	Not Specified	MGI:3603538
cx2	Casp3^tm1Flv/Casp3^tm1Flv Casp6^tm1Flv/Casp6^tm1Flv	involves: 129S1/Sv * C57BL/6J	MGI:3603541

Genotype
MGI:3603538

hm1

• Allelic Composition: Casp6^tm1Flv/Casp6^tm1Flv
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:101037 )

N • lenses appear grossly normal

N • no change in the distance between the equatorial surface of the lens and the border of the organelle free zone

N • lens extracts display normal levels of lysis of fluorogenic substrate VEID-AMC

abnormal lens development ( J:101037 )

• staurosporine treatment of lenses fails to induce increased lysis of fluorogenic substrate VEID-AMC as it does in wild-type lenses

cellular

cellular phenotype ( J:59875 )

N • normal phosphatidyl serine flip-flop in thymocytes treated with dexamethasone

Genotype
MGI:3603541

cx2

• Allelic Composition: Casp3^tm1Flv/Casp3^tm1Flv; Casp6^tm1Flv/Casp6^tm1Flv
• Genetic Background: involves: 129S1/Sv * C57BL/6J

growth/size/body

decreased body size ( J:101037 )

• slightly smaller than normal

vision/eye

vision/eye phenotype ( J:101037 )

N • normal tissue organization in the equatorial lens and normal denucleation process in lens

anterior polar cataract ( J:101037 )

• anterior polar cataracts are more pronounced than in mice disrupted for only caspase 3

microphthalmia ( J:101037 )

• incomplete penetrence, occurs in less than half the mice

anophthalmia ( J:101037 )

• incomplete penetrence