Phenotypes associated with this allele

• Allele Symbol: Grm8^tm1Duv
• Allele Name: targeted mutation 1, Robert M Duvoisin
• Allele ID: MGI:3603321
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grm8^tm1Duv/Grm8^tm1Duv	B6.129S1-Grm8^tm1Duv	MGI:3607796

Genotype
MGI:3607796

hm1

• Allelic Composition: Grm8^tm1Duv/Grm8^tm1Duv
• Genetic Background: B6.129S1-Grm8^tm1Duv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body weight ( J:101087 )

• on a regular or high fat diet homozygotes weigh 8% or 9%, respectively, more than wild-type mice; however no significant difference in food intake is seen

adipose tissue

increased percent body fat/body weight ( J:101087 )

• both lean mass and percent body fat are increased compared to wild-type mice

homeostasis/metabolism

insulin resistance ( J:101087 )

• homozygotes display a slight resistance to insulin but normal glucose tolerance

behavior/neurological

decreased exploration in new environment ( J:101087 )

• for the first 3 days after introduction to a novel enclosed environment homozygotes travel less total distance in the first hour, after 3 days wild-type and homozygous mice travel similar distances

• however, exploration of novel objections and performance in a Morris water maze test are normal

increased anxiety-related response ( J:101087 )

• homozygotes spend less time, enter less often, and travel less in the center of an open field or the open arm of an elevated plus maze

impaired swimming ( J:101087 )

• homozygotes swim slightly but significantly slower than wild-type mice