Phenotypes associated with this allele

• Allele Symbol: Epha4^tm6Kln
• Allele Name: targeted mutation 6, Rudiger Klein
• Allele ID: MGI:3603431
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Epha4^tm6Kln/Epha4^tm6Kln	involves: 129S/SvEv * C57BL/6	MGI:3608664
hm2	Epha4^tm6Kln/Epha4^tm6Kln	involves: 129/Sv * C57BL/6	MGI:3694674

Genotype
MGI:3608664

hm1

• Allelic Composition: Epha4^tm6Kln/Epha4^tm6Kln
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

ectopic thalamus ( J:101019 )

• in 61% of homozygotes thalamic neurons are located more medially than in wild-type mice; however, anterior commissure and corticospinal tract morphology are normal

abnormal central pattern generator function ( J:101019 )

• bilateral lumbar 2 ventral roots display normal alternating bursts but at L5 an increase in synchronous bursts is seen in some homozygotes; however the walking gait of homozygotes is normal

Genotype
MGI:3694674

hm2

• Allelic Composition: Epha4^tm6Kln/Epha4^tm6Kln
• Genetic Background: involves: 129/Sv * C57BL/6

nervous system

abnormal primary somatosensory cortex morphology ( J:115279 )

abnormal barrel cortex morphology ( J:115279 )

abnormal innervation ( J:115279 )

• 61% of mice display abnormal TC projections from the ventro-posterior-medial (VPM) part of the ventro-basal nucleus (VB) to the primary somatosensory area S1, with cells located at ectopic positions with respect to the position corresponding to normal barreloid clusters