Phenotypes associated with this allele

• Allele Symbol: Lrp8^tm2.1Her
• Allele Name: targeted mutation 2.1, Joachim Herz
• Allele ID: MGI:3603433
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrp8^tm2.1Her/Lrp8^tm2.1Her	involves: 129S6/SvEvTac	MGI:3699088
hm2	Lrp8^tm2.1Her/Lrp8^tm2.1Her	involves: 129S6/SvEvTac * C57BL/6J	MGI:3608674

Genotype
MGI:3699088

hm1

• Allelic Composition: Lrp8^tm2.1Her/Lrp8^tm2.1Her
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased motor neuron number ( J:117956 )

• corticospinal neuron (CSN) numbers are reduced ~36%

neuron degeneration ( J:117956 )

• lipofuscin autofluorescence is prominent in the neocortex, entorhinal cortex, basal nucleus of Meynert and hippocampus, indicative of degenerative processes

cellular

abnormal cell death ( J:117956 )

• in mutants, corticospinal neurons are resistant to lesion-induced cell death whereas ~40% of wild-type CSN die after CSN deafferentation at 4 months of age

Genotype
MGI:3608674

hm2

• Allelic Composition: Lrp8^tm2.1Her/Lrp8^tm2.1Her
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

normal phenotype

no abnormal phenotype detected ( J:100988 )

• long term potentiation, contextual conditioning, and spatial learning are normal