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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ppiftm1.1Mmos
targeted mutation 1.1, Michael A Moskowitz
MGI:3603458
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ppiftm1.1Mmos/Ppiftm1.1Mmos involves: 129X1/SvJ * FVB/NJ MGI:3608595
ht2
 		Ppiftm1.1Mmos/Ppif+ involves: 129X1/SvJ * FVB/NJ MGI:3608596


Genotype
MGI:3608595
hm1
Allelic
Composition		 Ppiftm1.1Mmos/Ppiftm1.1Mmos
Genetic
Background		 involves: 129X1/SvJ * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppiftm1.1Mmos mutation (1 available); any Ppif mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal mitochondrial physiology ( J:101149 )
• cultured embryonic fibroblasts from homozygotes are less susceptible to H2O2 induced cell death but respond normally to etoposide, staurosporine, thapsigargin, tunicamycin, brefeldin A, tumor necrosis factor alpha and TNFSF10
• 100uM CaCl2 fails to induce mitochondiral swelling in mitochondria from homozygous liver

nervous system
nervous system phenotype ( J:101149 )
N
• normal brain and cerebrovasculature
decreased cerebral infarct size ( J:101149 )
• infarct volume induced by middle cerebral artery occlusion is reduced by 62% in homozygotes relative to wild-type siblings

homeostasis/metabolism
decreased cerebral infarct size ( J:101149 )
• infarct volume induced by middle cerebral artery occlusion is reduced by 62% in homozygotes relative to wild-type siblings




Genotype
MGI:3608596
ht2
Allelic
Composition		 Ppiftm1.1Mmos/Ppif+
Genetic
Background		 involves: 129X1/SvJ * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppiftm1.1Mmos mutation (1 available); any Ppif mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased cerebral infarct size ( J:101149 )
• infarct volume induced by middle cerebral artery occlusion is reduced by 37% in heterozygotes relative to wild-type siblings

homeostasis/metabolism
decreased cerebral infarct size ( J:101149 )
• infarct volume induced by middle cerebral artery occlusion is reduced by 37% in heterozygotes relative to wild-type siblings




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory