All Phenotypes Avpr1a<tm1Sbhu> MGI Mouse

Phenotypes associated with this allele

Allelic Composition	Avpr1a^tm1Sbhu/Avpr1a^tm1Sbhu
Genetic Background	129X1.Cg-Avpr1a^tm1Sbhu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Avpr1a^tm1Sbhu mutation (0 available); any Avpr1a mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased anxiety-related response ( J:101024 , J:101213 )

	• females did not display any change in anxiety-like behavior (J:101024)
	• males exhibited significantly less anxiety-like behavior in all tests while overall activity was not affected (J:101213) • more time in open arms of elevated maze by males (J:101213) • more time in inner areas of open field by males (J:101213) • more time in light box of light/dark box by males (J:101213)

abnormal social investigation ( J:101213 )

• deficient social recognition by males

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:105892 )

• decreased IgM^highIgD^high B cells in the spleen and increased IgM^lowIgD^high

increased B-1a cell number ( J:105892 )

• increased numbers of B-1a cells

abnormal immunoglobulin level ( J:105892 )

• increased response to T-cell dependent antigens (involving IgG1 and IgG2b)

• no difference in response to T-cell independent antigens

increased IgG2a level ( J:105892 )

• increased IgG2a levels in serum

decreased IgG2b level ( J:105892 )

• decreased IgG2b levels in serum

hematopoietic system