Phenotypes associated with this allele

• Allele Symbol: Mchr1^tm1Blak
• Allele Name: targeted mutation 1, Bernard Lakaye
• Allele ID: MGI:3603521
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mchr1^tm1Blak/Mchr1^tm1Blak	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3608485

Genotype
MGI:3608485

hm1

• Allelic Composition: Mchr1^tm1Blak/Mchr1^tm1Blak
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal passive avoidance behavior ( J:101206 )

• the post-shock latencies in the first retention test are reduced compared to wild-type mice and in the second retention test homozygotes do not display any inhibitory avoidance unlike wild-type mice

nervous system

abnormal nervous system electrophysiology ( J:101206 )

• depolarization evoked by 3 or 6 uM N-methyl d-aspartate (NMDA) in CA1 pyramidal neurons is increased compared to wild-type mice; however resting membrane potential, resistance, action potential characteristics, and excitability are all normal

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:101206 )

growth/size/body

decreased susceptibility to diet-induced obesity ( J:101206 )