Phenotypes associated with this allele

• Allele Symbol: Bace1^tm2Psa
• Allele Name: targeted mutation 2, Paul Saftig
• Allele ID: MGI:3603597
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bace1^tm2Psa/Bace1^tm2Psa	involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6	MGI:3607590

Genotype
MGI:3607590

hm1

• Allelic Composition: Bace1^tm2Psa/Bace1^tm2Psa
• Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:100925 )

• similar mortality rate as homozygous Bace1^tm1Psa mice, with some dying in the first 3-6 days and some by 3-4 weeks of age

behavior/neurological

decreased anxiety-related response ( J:100925 )

• exhibit an increase in the time spent in open arms and an increase in the total distance traveled in elevated zero maze test

increased locomotor activity ( J:100925 )

• exhibit a significant increase in total move time and total distance traveled, however no differences in the time spent and distance traveled in the center