Analysis Tools
mortality/aging
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• in spite of the presence of increased cell markers for senescence, no obvious manifestations of premature aging are seen in mice
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behavior/neurological
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• excessive numbers of errors in a Barnes circular maze in early trials, due to increased exploration
• increased exploratory behavior during olfaction tests slowed success in finding target
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• at some time points, homozygotes perform better on an accelerating rotarod than do controls
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cellular
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• abnormal nuclear morphology seen in cells in culture at later passages
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• increased ATP levels develop in cultured embryonic fibroblasts after passage 5 and at passage 1 in adult fibroblasts
• increased ATP levels are not seen in cells of the cortex and skeletal muscle of 14 month old mice
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• cell senescence markers are seen to increase in cells in culture and in brain sections from year old mice
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• reduced cell proliferation in culture
• cell density only 30% normal at passage 6
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