Phenotypes associated with this allele

• Allele Symbol: Sstr5^tm1Hawi
• Allele Name: targeted mutation 1, Hilary A Wilkinson
• Allele ID: MGI:3603655
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sstr5^tm1Hawi/Sstr5^tm1Hawi	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3603656

Genotype
MGI:3603656

hm1

• Allelic Composition: Sstr5^tm1Hawi/Sstr5^tm1Hawi
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased insulin secretion ( J:101259 )

• basal and glucose-stimulated insulin secretion rates are increased as is the insulin content of the pancreatic islets; however the fold-increase in insulin secretion in response to glucose and basal glucagon secretion are similar to wild-type

• in 12 week old male homozygotes no difference is seen in the number, size, or distibution of pancreatic islets compared to wild-type mice

homeostasis/metabolism

increased insulin secretion ( J:101259 )

• basal and glucose-stimulated insulin secretion rates are increased as is the insulin content of the pancreatic islets; however the fold-increase in insulin secretion in response to glucose and basal glucagon secretion are similar to wild-type

• in 12 week old male homozygotes no difference is seen in the number, size, or distibution of pancreatic islets compared to wild-type mice

decreased circulating glucose level ( J:101259 )

• on a normal chow diet postprandial and fasting blood glucose levels are decreased compared to wild-type

• on a high fat diet glucose levels increase in both homozygous and wild-type mice but the difference in blood glucose level persists

increased circulating glucagon level ( J:101259 )

• on a normal chow diet postprandial and fasting blood glucagon levels are increased compared to wild-type

decreased circulating insulin level ( J:101259 )

• on a normal chow diet postprandial and fasting blood insulin levels are decreased compared to wild-type

• after 6 weeks on a high fat diet postprandial insulin levels increase by about 48% in homozygotes compared to about 320% in wild-type mice

increased circulating leptin level ( J:101259 )

• a 2.6-fold increase in fasting plasma leptin levels is seen on a normal chow diet; however after 6 weeks on a high fat diet no difference in leptin levels is found

improved glucose tolerance ( J:101259 )

• after 6 weeks on a high fat diet homozygotes clear glucose more rapidly than wild-type mice

increased insulin sensitivity ( J:101259 )

• insulin sensitivity is increased on both a normal chow and high fat diets

growth/size/body

decreased body weight ( J:101259 )

• on a high fat diet homozygotes display a transient delay in weight gain