Analysis Tools
endocrine/exocrine glands
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• abnormally large islets with pleomorphic cells of variable size and shape are seen at 20 weeks of age
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• 6 of 33 homozygous floxed mutants had adenomas by the date of the scheduled autopsy and tumor incidence in homozygous mutants correlates to the level of Cre expression for the different cre transgenes
• a mild sex bias is seen with 3 of 12 virgin females developing adenomas compared to 3 of 21 males
• adenomas are detected by 44 weeks of age
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homeostasis/metabolism
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• fasting blood glucose levels are decreased
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• fasting serum insulin levels are increased
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neoplasm
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• 6 of 33 homozygous floxed mutants had adenomas by the date of the scheduled autopsy and tumor incidence in homozygous mutants correlates to the level of Cre expression for the different cre transgenes
• a mild sex bias is seen with 3 of 12 virgin females developing adenomas compared to 3 of 21 males
• adenomas are detected by 44 weeks of age
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