Phenotypes associated with this allele

• Allele Symbol: Slc26a6^tm1Sole
• Allele Name: targeted mutation 1, Manoocher Soleimani
• Allele ID: MGI:3603678
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc26a6^tm1Sole/Slc26a6^tm1Sole	involves: 129S6/SvEvTac	MGI:3839149
hm2	Slc26a6^tm1Sole/Slc26a6^tm1Sole	involves: 129S6/SvEvTac * C57BL/6J	MGI:3605027

Genotype
MGI:3839149

hm1

• Allelic Composition: Slc26a6^tm1Sole/Slc26a6^tm1Sole
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal digestive system physiology ( J:121543 )

• rates of HCO3- influx during Cl- removal and HCO3- efflux during Cl- replacement in villi epithelia are decreased by 65% to 80% compared to in wild-type cells

• the sulfate ions/bicarbonate exchange is eliminated in duodenum epithelium

• baseline pH in villous epithelia is increased compared to in wild-type cells

• however, baseline pH is increased to wild-type levels in the absence of carbon dioxide/bicarbonate ions or during methazolamide treatment

Genotype
MGI:3605027

hm2

• Allelic Composition: Slc26a6^tm1Sole/Slc26a6^tm1Sole
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

renal/urinary system

abnormal kidney physiology ( J:101233 )

• in the proximal tubules baseline pHi is decreased to 7.38+/-0.02 compared to 7.49+/-0.01 in wild-type mice and the rate of apical Cl/HCO₃- exchanger activity is decreased by 58%

• oxalate does not increase the rate of fluid absorption unlike in wild-type mice; however the baseline rate of fluid absorption is normal

digestive/alimentary system

abnormal digestive system physiology ( J:101233 )

• basal, but not forskolin-stimulated, HCO₃- secretion is decreased 30.5% in mucosal duodenal tissue and in the presence of an outward pH and HCO₃- gradient uptake of Cl- is decreased by about 39% in apical membrane vesicles from the duodenum