All Phenotypes Erbb4<tm1Htig> MGI Mouse

premature death ( J:101252 )

• die within the first year of life

abnormal myocardial fiber morphology ( J:101252 )

• cardiomyocyte length is increased and they exhibit enlarged nuclei with a significantly higher rate of polyploidy at 3 months of age

• dilation of tubular membrane system in myocytes with normal myofibrils and mitochondria

abnormal intercalated disk morphology ( J:101252 )

• number of intercalated disks per unit area of ventricular muscle is reduced

decreased myocardial fiber number ( J:101252 )

• number of nuclei per unit area of ventricular muscle is reduced

enlarged heart ( J:101252 )

• exhibit higher heart-to-body weight ratios than wildtype at 3 months of age

cardiac hypertrophy ( J:101252 )

• hearts are enlarged, however observe no differences in cardiomyocyte cell number, proliferation or apoptosis

dilated heart left ventricle ( J:101252 )

• dilation evident by 3 months of age but is not seen in neonates

thin ventricular wall ( J:101252 )

• evident by 3 months of age

dilated heart right ventricle ( J:101252 )

• dilation evident by 3 months of age but is not seen in neonates

dilated cardiomyopathy ( J:101252 )

decreased heart left ventricle muscle contractility ( J:101252 )

• retrograde perfusion of the left ventricle in isolated hearts shows a reduction of the maximal left ventricular developed pressure, demonstrating depressed myocardial contractility

ventricular tachycardia ( J:101252 )

• programmed intracardiac stimulation shows increased susceptibility to ventricular tachycardia

abnormal impulse conducting system conduction ( J:101252 )

• ECG at 2-3 months of age shows widened QRS complex and Q-Tc intervals, indicating delayed conduction

prolonged QRS complex duration ( J:101252 )

• ECG at 2-3 months of age shows widened QRS complex

prolonged QT interval ( J:101252 )

• 12.5% prolongation in Q-Tc intervals