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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(PDGFB-APPSweIndArc)48Lms
transgene insertion 48, Lennart Mucke
MGI:3603941
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
 		Tg(PDGFB-APPSweIndArc)48Lms/0 B6.Cg-Tg(PDGFB-APPSweIndArc)48Lms MGI:3611046


Genotype
MGI:3611046
tg1
Allelic
Composition		 Tg(PDGFB-APPSweIndArc)48Lms/0
Genetic
Background		 B6.Cg-Tg(PDGFB-APPSweIndArc)48Lms
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
amyloid beta deposits ( J:100954 )
• by 2 months of age, mice have many neuritic plaques
• mice develop striking parenchymal plaques but show no obvious increase in cerebrovascular amyloid deposition compared to Tg(PDGFB-APPSwInd)20Lms mice
abnormal neuron morphology ( J:100954 )
• dystrophic neurites are associated with plaques

homeostasis/metabolism
amyloidosis ( J:100954 )
• at 2-4 weeks, mice have 2.2-3.5-fold higher Abeta(1-x) levels compared to Tg(PDGFB-APPSwInd)20Lms or Tg(PDGFB-APPSweIndArc)6Lms mice
amyloid beta deposits ( J:100954 )
• by 2 months of age, mice have many neuritic plaques
• mice develop striking parenchymal plaques but show no obvious increase in cerebrovascular amyloid deposition compared to Tg(PDGFB-APPSwInd)20Lms mice




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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory