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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Prdx6)153Pgn
transgene insertion 153, Beverly J Paigen
MGI:3604080
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Prdx6)153Pgn/0 C57BL/6-Tg(Prdx6)153Pgn/Pgn MGI:3844865


Genotype
MGI:3844865
tg1
Allelic
Composition
Tg(Prdx6)153Pgn/0
Genetic
Background
C57BL/6-Tg(Prdx6)153Pgn/Pgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prdx6)153Pgn mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice exposed to hyperoxic conditions exhibit delayed mortality compared to similarly treated wild-type mice

immune system
• exhibit reduced hydrogen peroxide compared to in similarly treated wild-type mice

homeostasis/metabolism
N
• mice fed a high fat diet, exhibit normal HDL concentrations
• under hyperoxic conditions, mice exhibit decreased response; less severe lung injury, including reduced increase in lung wet:dry weight ratio, necrosis of bronchiolar epithelium, perivascular and alveolar edema, and number of inflammatory cells in the airspaces; and delayed mortality compared with wild-type mice

cardiovascular system
N
• mice fed a high fat diet develop normal atherosclerotic lesions

hematopoietic system
• exhibit reduced hydrogen peroxide compared to in similarly treated wild-type mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory