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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Liastm1Mae
targeted mutation 1, Nobuyo Maeda
MGI:3604218
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Liastm1Mae/Liastm1Mae either: 129S6/SvEvTac-Liastm1Mae or (involves: 129S6/SvEvTac * C57BL/6J) MGI:3604779
ht2
 		Liastm1Mae/Lias+ either: 129S6/SvEvTac-Liastm1Mae or (involves: 129S6/SvEvTac * C57BL/6J) MGI:3604780
ht3
 		Liasnehe/Liastm1Mae involves: 129S6/SvEvTac * C57BL/6J MGI:4830284


Genotype
MGI:3604779
hm1
Allelic
Composition		 Liastm1Mae/Liastm1Mae
Genetic
Background		 either: 129S6/SvEvTac-Liastm1Mae or (involves: 129S6/SvEvTac * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Liastm1Mae mutation (1 available); any Lias mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between somite formation and embryo turning, complete penetrance ( J:101368 )
• homozygous embryos die between E7.5 and E9.5
• even with lipoic acid supplementation of the dams no live born homozygotes are found

embryo
embryonic growth arrest ( J:101368 )
• embryos appear to stop growing at the egg cylinder stage
decreased embryo size ( J:101368 )
• embryos are smaller at E7.5

growth/size/body
decreased embryo size ( J:101368 )
• embryos are smaller at E7.5




Genotype
MGI:3604780
ht2
Allelic
Composition		 Liastm1Mae/Lias+
Genetic
Background		 either: 129S6/SvEvTac-Liastm1Mae or (involves: 129S6/SvEvTac * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Liastm1Mae mutation (1 available); any Lias mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased glutathione level ( J:101368 )
• levels of glutathione in erythrocytes are significantly reduced; however plasma glucose, triglyceride, and cholesterol levels are normal and no increase in thiobarbituric acid-reactive substances (TBARS, a measure of oxidative stress) is seen




Genotype
MGI:4830284
ht3
Allelic
Composition		 Liasnehe/Liastm1Mae
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Liasnehe mutation (0 available); any Lias mutation (26 available)
Liastm1Mae mutation (1 available); any Lias mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
rostral body truncation ( J:163880 )
• mice exhibit anterior truncation compared with wild-type mice
embryonic growth retardation ( J:163880 )
• more severe than in Liasnehe homozygotes

growth/size/body
embryonic growth retardation ( J:163880 )
• more severe than in Liasnehe homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory