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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr148tm1Fwa
targeted mutation 1, Frederick W Alt
MGI:3604299
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rr148tm1Fwa/Rr148tm1Fwa 129S6/SvEvTac-Rr148tm1Fwa MGI:3608487
cx2
 		Rr148tm1Fwa/Rr148tm1Fwa
Rag2tm1Fwa/Rag2tm1Fwa 		involves: 129S/SvEv * 129S6/SvEvTac MGI:3608489


Genotype
MGI:3608487
hm1
Allelic
Composition		 Rr148tm1Fwa/Rr148tm1Fwa
Genetic
Background		 129S6/SvEvTac-Rr148tm1Fwa
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested B cell differentiation ( J:101400 )
• PCR fails to amplify D to JH and VH to DJH rearrangements from bone marrow cell extracts
• complete arrest of arrest of B cell development in bone marrow at B220int Kit+ and/or B220int Kit+ ProB1 stage
absent B cells ( J:101400 )
• no peripheral B cells
spleen hypoplasia ( J:101400 )
• 70% reduction in total number of splenocytes

immune system
arrested B cell differentiation ( J:101400 )
• PCR fails to amplify D to JH and VH to DJH rearrangements from bone marrow cell extracts
• complete arrest of arrest of B cell development in bone marrow at B220int Kit+ and/or B220int Kit+ ProB1 stage
absent B cells ( J:101400 )
• no peripheral B cells
spleen hypoplasia ( J:101400 )
• 70% reduction in total number of splenocytes




Genotype
MGI:3608489
cx2
Allelic
Composition		 Rr148tm1Fwa/Rr148tm1Fwa
Rag2tm1Fwa/Rag2tm1Fwa
Genetic
Background		 involves: 129S/SvEv * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (119 available)
Rr148tm1Fwa mutation (0 available); any Rr148 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell differentiation ( J:101400 )
• CD19 enriched bone marrow cells have decreased Imu transcripts and no mu0 transcripts are detectable

immune system
abnormal B cell differentiation ( J:101400 )
• CD19 enriched bone marrow cells have decreased Imu transcripts and no mu0 transcripts are detectable




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory