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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr148tm1.1Fwa
targeted mutation 1.1, Frederick W Alt
MGI:3604300
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rr148tm1.1Fwa/Rr148tm1.1Fwa involves: 129S6/SvEvTac MGI:3608488
cx2
 		Rr148tm1.1Fwa/Rr148tm1.1Fwa
Rag2tm1Fwa/Rag2tm1Fwa 		involves: 129S/SvEv * 129S6/SvEvTac MGI:3608490


Genotype
MGI:3608488
hm1
Allelic
Composition		 Rr148tm1.1Fwa/Rr148tm1.1Fwa
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell differentiation ( J:101400 )
• PCR of bone marrow cell extracts detects decreased VH to DJH rearrangements with minimal decrease in D to JH rearrangements
decreased immature B cell number ( J:101400 )
• decreased immature IgM+ B cells
arrested B cell differentiation ( J:101400 )
• arrest of B cell development is less severe than in Ihgtm1Fwa homozygotes and is evidenced by increased bone marrow B220int CD43+ pro-B cells and a decrease in B220+ CD43int pre-B cells
spleen hypoplasia ( J:101400 )
• 50% reduction in total number of splenocytes

immune system
immune system phenotype ( J:101400 )
N
• normal Peyers patches
• mature peripheral B cells have normal surface IgM and IgD expresssion
• Peripheral and thymic T cells are present in normal numbers and proportions
• normal somatic hypermutation frequency is found in Peyers patch germinal center B cells
• class switching is, at most, modestly diminished in LPS or anti-CD40/IL4 induced splenocytes
abnormal B cell differentiation ( J:101400 )
• PCR of bone marrow cell extracts detects decreased VH to DJH rearrangements with minimal decrease in D to JH rearrangements
decreased immature B cell number ( J:101400 )
• decreased immature IgM+ B cells
arrested B cell differentiation ( J:101400 )
• arrest of B cell development is less severe than in Ihgtm1Fwa homozygotes and is evidenced by increased bone marrow B220int CD43+ pro-B cells and a decrease in B220+ CD43int pre-B cells
spleen hypoplasia ( J:101400 )
• 50% reduction in total number of splenocytes




Genotype
MGI:3608490
cx2
Allelic
Composition		 Rr148tm1.1Fwa/Rr148tm1.1Fwa
Rag2tm1Fwa/Rag2tm1Fwa
Genetic
Background		 involves: 129S/SvEv * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (119 available)
Rr148tm1.1Fwa mutation (0 available); any Rr148 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell differentiation ( J:101400 )
• CD19 enriched bone marrow cells have decreased Imu and mu0 transcripts

immune system
abnormal B cell differentiation ( J:101400 )
• CD19 enriched bone marrow cells have decreased Imu and mu0 transcripts




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory