Phenotypes associated with this allele

• Allele Symbol: Gdf6^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3604391
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gdf6^tm1Lex/Gdf6^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:3609960

Genotype
MGI:3609960

hm1

• Allelic Composition: Gdf6^tm1Lex/Gdf6^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:103485 )

• exhibit reduced viability with fewer homozygotes detected at weaning

growth/size/body

decreased body weight ( J:103485 )

• surviving homozygotes exhibit decreased mean body weight, total tissue mass, and lean body mass

postnatal growth retardation ( J:103485 )

skeleton

abnormal skeleton morphology ( J:103485 )

• exhibit decreased bone-related measurements

nervous system

abnormal optic disk morphology ( J:103485 )

• exhibit signs of optic disc edema

vision/eye

abnormal optic disk morphology ( J:103485 )

• exhibit signs of optic disc edema

hearing/vestibular/ear

abnormal hearing physiology ( J:103485 )

• exhibit a possible hearing impairment