Phenotypes associated with this allele

• Allele Symbol: Polq^tm1Jow
• Allele Name: targeted mutation 1, Jiyang O-Wang
• Allele ID: MGI:3604448
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Polq^tm1Jow/Polq^tm1Jow	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:3695307

Genotype
MGI:3695307

hm1

• Allelic Composition: Polq^tm1Jow/Polq^tm1Jow
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal somatic hypermutation frequency ( J:101409 )

• a slight reduction in total somatic hypermutation in the JH4 intronic region in germinal center B cells that is mostly related to a 41% reduction in mutations at C/G

abnormal B cell physiology ( J:101409 )

• significant reduction in production of high-affinity antibodies in response to a T-dependent antigen

decreased immunoglobulin level ( J:101409 )

• general decrease in serum Ig levels, except for IgA

decreased IgG level ( J:101409 )

• significant decrease in serum IgG1 and slight but non-significant reduction in IgG2a, IgG2b, and IgG3

decreased IgG1 level ( J:101409 )

decreased IgM level ( J:101409 )

hematopoietic system

abnormal somatic hypermutation frequency ( J:101409 )

• a slight reduction in total somatic hypermutation in the JH4 intronic region in germinal center B cells that is mostly related to a 41% reduction in mutations at C/G

abnormal B cell physiology ( J:101409 )

• significant reduction in production of high-affinity antibodies in response to a T-dependent antigen

decreased immunoglobulin level ( J:101409 )

• general decrease in serum Ig levels, except for IgA

decreased IgG level ( J:101409 )

• significant decrease in serum IgG1 and slight but non-significant reduction in IgG2a, IgG2b, and IgG3

decreased IgG1 level ( J:101409 )

decreased IgM level ( J:101409 )