Phenotypes associated with this allele

• Allele Symbol: Tcra-J^tm1Slek
• Allele Name: targeted mutation 1, Barry P Sleckman
• Allele ID: MGI:3604459
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tcra-J^tm1Slek/Tcra-J^tm1Slek	involves: 129P2/OlaHsd	MGI:3715865

Genotype
MGI:3715865

hm1

• Allelic Composition: Tcra-J^tm1Slek/Tcra-J^tm1Slek
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased thymocyte number ( J:101398 )

• increase is mainly in double negative thymocytes

abnormal T cell differentiation ( J:101398 )

• double positive TCR beta^low cells accumulate

• single positive cell generation from double positive cells is impaired

increased double-negative T cell number ( J:101398 )

• increase is in double negative thymocytes

decreased double-positive T cell number ( J:101398 )

• mature double positive alpha beta TCR cell are decreased

decreased single-positive T cell number ( J:101398 )

• decrease in single positive thymocytes

hematopoietic system

increased thymocyte number ( J:101398 )

• increase is mainly in double negative thymocytes

abnormal T cell differentiation ( J:101398 )

• double positive TCR beta^low cells accumulate

• single positive cell generation from double positive cells is impaired

increased double-negative T cell number ( J:101398 )

• increase is in double negative thymocytes

decreased double-positive T cell number ( J:101398 )

• mature double positive alpha beta TCR cell are decreased

decreased single-positive T cell number ( J:101398 )

• decrease in single positive thymocytes

endocrine/exocrine glands

increased thymocyte number ( J:101398 )

• increase is mainly in double negative thymocytes