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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ppm1gtm1Dgen
targeted mutation 1, Deltagen
MGI:3604466
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ppm1gtm1Dgen/Ppm1gtm1Dgen involves: 129P2/OlaHsd * C57BL/6 MGI:3606459
ht2
 		Ppm1gtm1Dgen/Ppm1g+ involves: 129P2/OlaHsd * C57BL/6 MGI:3606460


Genotype
MGI:3606459
hm1
Allelic
Composition		 Ppm1gtm1Dgen/Ppm1gtm1Dgen
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppm1gtm1Dgen mutation (1 available); any Ppm1g mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:101679 )
• homozygotes frequently do not survive to weaning age




Genotype
MGI:3606460
ht2
Allelic
Composition		 Ppm1gtm1Dgen/Ppm1g+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppm1gtm1Dgen mutation (1 available); any Ppm1g mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased prepulse inhibition ( J:101679 )
• exhibit a significant decrease in prepulse inhibition when compared to age- and gender-matched wildtype controls, indicating a stimulus processing deficit that is observed in some schizophrenic patients

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
schizophrenia DOID:5419 OMIM:181500
 J:101679




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory