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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gria4tm1Dgen
targeted mutation 1, Deltagen
MGI:3604485
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gria4tm1Dgen/Gria4tm1Dgen involves: 129P2/OlaHsd * C57BL/6 MGI:3606457
hm2
 		Gria4tm1Dgen/Gria4tm1Dgen involves: 129P2/OlaHsd * C57BL/6J MGI:3795133
ht3
 		Gria4tm1Dgen/Gria4+ involves: 129P2/OlaHsd * C57BL/6J MGI:3795132
ht4
 		Gria4spkw1/Gria4tm1Dgen involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6J MGI:3795121


Genotype
MGI:3606457
hm1
Allelic
Composition		 Gria4tm1Dgen/Gria4tm1Dgen
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria4tm1Dgen mutation (2 available); any Gria4 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal seizure response to pharmacological agent ( J:101679 )
• higher doses of metrazol are needed to induce some seizure stages while lower doses are needed to induce other stages
increased locomotor activity ( J:101679 )
• increase in the total the distance traveled in an open field
increased thermal nociceptive threshold ( J:101679 )
• prolonged latency in hot plate test

nervous system
abnormal seizure response to pharmacological agent ( J:101679 )
• higher doses of metrazol are needed to induce some seizure stages while lower doses are needed to induce other stages




Genotype
MGI:3795133
hm2
Allelic
Composition		 Gria4tm1Dgen/Gria4tm1Dgen
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria4tm1Dgen mutation (2 available); any Gria4 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
absence seizures ( J:135814 )
• all compound mutants display a high incidence (90 SWD/hr) of spike wave discharge (SWD)

nervous system
absence seizures ( J:135814 )
• all compound mutants display a high incidence (90 SWD/hr) of spike wave discharge (SWD)




Genotype
MGI:3795132
ht3
Allelic
Composition		 Gria4tm1Dgen/Gria4+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria4tm1Dgen mutation (2 available); any Gria4 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
absence seizures ( J:135814 )
• the spike wave discharge incidence observed in the F1 C3H intercross is slightly lower than that observed in homozygous C3H/HeJ animals

nervous system
absence seizures ( J:135814 )
• the spike wave discharge incidence observed in the F1 C3H intercross is slightly lower than that observed in homozygous C3H/HeJ animals




Genotype
MGI:3795121
ht4
Allelic
Composition		 Gria4spkw1/Gria4tm1Dgen
Genetic
Background		 involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria4spkw1 mutation (4 available); any Gria4 mutation (72 available)
Gria4tm1Dgen mutation (2 available); any Gria4 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
absence seizures ( J:135814 )
• all compound mutants display a high incidence (90 SWD/hr) of spike wave discharge (SWD)

nervous system
absence seizures ( J:135814 )
• all compound mutants display a high incidence (90 SWD/hr) of spike wave discharge (SWD)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory