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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gria3tm1Dgen
targeted mutation 1, Deltagen
MGI:3604486
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gria3tm1Dgen/Gria3tm1Dgen involves: 129P2/OlaHsd * C57BL/6 MGI:3606450
hm2
 		Gria3tm1Dgen/Gria3tm1Dgen involves: 129P2/OlaHsd * C57BL/6J MGI:3795130
cx3
 		Gria3tm1Dgen/Gria3tm1Dgen
Gria4spkw1/Gria4spkw1 		involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6J MGI:3795127
ot4
 		Gria3tm1Dgen/Y involves: 129P2/OlaHsd * C57BL/6 MGI:3628569


Genotype
MGI:3606450
hm1
Allelic
Composition		 Gria3tm1Dgen/Gria3tm1Dgen
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria3tm1Dgen mutation (2 available); any Gria3 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:101679 )
• at 300 days of age body weight, body mass, and/or body weight to length ratios are reduced




Genotype
MGI:3795130
hm2
Allelic
Composition		 Gria3tm1Dgen/Gria3tm1Dgen
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria3tm1Dgen mutation (2 available); any Gria3 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:135814 )
N
• mice show no spike wave discharge (SWD)
• with age, no ataxia is observed




Genotype
MGI:3795127
cx3
Allelic
Composition		 Gria3tm1Dgen/Gria3tm1Dgen
Gria4spkw1/Gria4spkw1
Genetic
Background		 involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria3tm1Dgen mutation (2 available); any Gria3 mutation (12 available)
Gria4spkw1 mutation (4 available); any Gria4 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
ataxia ( J:135814 )
• at 3 months of age, mice develop mild to moderate cerebellar ataxia compared to single mutant littermates
absence seizures ( J:135814 )
• double mutants have much lower incidence of spike wave discharge (SWD) than Gria4spkw1 homozygotes

nervous system
absence seizures ( J:135814 )
• double mutants have much lower incidence of spike wave discharge (SWD) than Gria4spkw1 homozygotes




Genotype
MGI:3628569
ot4
Allelic
Composition		 Gria3tm1Dgen/Y
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria3tm1Dgen mutation (2 available); any Gria3 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased susceptibility to pharmacologically induced seizures ( J:101679 )
• a higher dose of metrazol is needed to induce a first twitch stage of seizure response compared to wild-type mice
decreased startle reflex ( J:101679 )
• startle response is decreased in response to high intensity sound stimuli
increased thermal nociceptive threshold ( J:101679 )
• prolonged latency in hot plate test

nervous system
decreased susceptibility to pharmacologically induced seizures ( J:101679 )
• a higher dose of metrazol is needed to induce a first twitch stage of seizure response compared to wild-type mice




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory