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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc6a11tm1Dgen
targeted mutation 1, Deltagen
MGI:3604491
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Slc6a11tm1Dgen/Slc6a11tm1Dgen involves: 129P2/OlaHsd * C57BL/6 MGI:3606432
ht2
 		Slc6a11tm1Dgen/Slc6a11+ involves: 129P2/OlaHsd * C57BL/6 MGI:3606433


Genotype
MGI:3606432
hm1
Allelic
Composition		 Slc6a11tm1Dgen/Slc6a11tm1Dgen
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a11tm1Dgen mutation (1 available); any Slc6a11 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:101679 )
• homozygotes are rarely found at weaning




Genotype
MGI:3606433
ht2
Allelic
Composition		 Slc6a11tm1Dgen/Slc6a11+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a11tm1Dgen mutation (1 available); any Slc6a11 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased susceptibility to pharmacologically induced seizures ( J:101679 )
• a higher dose of metrazol is needed to induce various seizure stages compared to wild-type mice

nervous system
decreased susceptibility to pharmacologically induced seizures ( J:101679 )
• a higher dose of metrazol is needed to induce various seizure stages compared to wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory