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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cacna1ctm1Dgen
targeted mutation 1, Deltagen
MGI:3604527
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cacna1ctm1Dgen/Cacna1ctm1Dgen involves: 129P2/OlaHsd * C57BL/6 MGI:3606690
ht2
 		Cacna1ctm1Dgen/Cacna1c+ involves: 129P2/OlaHsd * C57BL/6 MGI:3606691


Genotype
MGI:3606690
hm1
Allelic
Composition		 Cacna1ctm1Dgen/Cacna1ctm1Dgen
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacna1ctm1Dgen mutation (1 available); any Cacna1c mutation (144 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:101679 )
• no homozygotes identified at weaning




Genotype
MGI:3606691
ht2
Allelic
Composition		 Cacna1ctm1Dgen/Cacna1c+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacna1ctm1Dgen mutation (1 available); any Cacna1c mutation (144 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased thigmotaxis ( J:101679 )
• avoid central areas in open field tests
impaired coordination ( J:101679 )
• significantly poorer performance on a rotarod test




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory