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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Xcr1tm1Dgen
targeted mutation 1, Deltagen
MGI:3604538
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Xcr1tm1Dgen/Xcr1tm1Dgen B6.129P2-Xcr1tm1Dgen/J MGI:4415313
hm2
 		Xcr1tm1Dgen/Xcr1tm1Dgen involves: 129P2/OlaHsd * C57BL/6 MGI:3606497


Genotype
MGI:4415313
hm1
Allelic
Composition		 Xcr1tm1Dgen/Xcr1tm1Dgen
Genetic
Background		 B6.129P2-Xcr1tm1Dgen/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xcr1tm1Dgen mutation (1 available); any Xcr1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:155297 )
N
• mice exhibit normal immune cell composition
abnormal dendritic cell physiology ( J:155297 )
• CD8+ dendritic cells fail to migrate in response to XCL1 unlike similarly treated wild-type cells




Genotype
MGI:3606497
hm2
Allelic
Composition		 Xcr1tm1Dgen/Xcr1tm1Dgen
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xcr1tm1Dgen mutation (1 available); any Xcr1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:101679 )
• no significant differences in physical examinations, necropsy including body length, body weight, and organ weight measurements, histological examination of tissues and organs, bone marrow section evaluations, complete blood counts and differentials, clinical chemistry panels, densitometry, behavior tests, fertility, or aging studies detected in the homozygous mutant mice when compared with age- and gender-matched wild-type control mice




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory