Phenotypes associated with this allele

• Allele Symbol: Thbs4^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:3604558
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Thbs4^tm1Dgen/Thbs4^tm1Dgen	B6.129P2-Thbs4^tm1Dgen	MGI:5437210
hm2	Thbs4^tm1Dgen/Thbs4^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6	MGI:3606662

Genotype
MGI:5437210

hm1

• Allelic Composition: Thbs4^tm1Dgen/Thbs4^tm1Dgen
• Genetic Background: B6.129P2-Thbs4^tm1Dgen

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal heart morphology ( J:187437 )

• in response to pressure overload, mice exhibit increased deposition of extracellular matrix compared with wild-type mice

abnormal coronary vessel morphology ( J:187437 )

• in response to pressure overload, mice exhibit decreased number of microvessels compared with wild-type mice

increased heart weight ( J:187437 )

• in response to pressure overload

cardiac hypertrophy ( J:187437 )

• in response to pressure overload

increased heart left ventricle weight ( J:187437 )

• in response to pressure overload

cardiac fibrosis ( J:187437 )

• in non-operated mice at 80 weeks of age

• in response to pressure overload

decreased heart ventricle muscle contractility ( J:187437 )

• in response to pressure overload

increased response of heart to induced stress ( J:187437 )

• in response to pressure overload, mice exhibit increased heart weight, cardiac hypertrophy, increased left ventricle and increased ejection fraction, decreased left ventricle end systolic volume, increased isovolumetric relaxation time, decreased number of microvessels, increased deposition of extracellular matrix and increased fibrosis compared with wild-type mice

• however, mice exhibit normal cardiomyocyte size and apoptosis

growth/size/body

increased heart weight ( J:187437 )

• in response to pressure overload

cardiac hypertrophy ( J:187437 )

• in response to pressure overload

decreased body weight ( J:187437 )

• in mice older than 80 weeks

homeostasis/metabolism

increased response of heart to induced stress ( J:187437 )

• in response to pressure overload, mice exhibit increased heart weight, cardiac hypertrophy, increased left ventricle and increased ejection fraction, decreased left ventricle end systolic volume, increased isovolumetric relaxation time, decreased number of microvessels, increased deposition of extracellular matrix and increased fibrosis compared with wild-type mice

• however, mice exhibit normal cardiomyocyte size and apoptosis

muscle

decreased heart ventricle muscle contractility ( J:187437 )

• in response to pressure overload

Genotype
MGI:3606662

hm2

• Allelic Composition: Thbs4^tm1Dgen/Thbs4^tm1Dgen
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

immune system

immune system phenotype ( J:301049 )

N • normal number of macrophages collected by peritoneal lavage after LPS-induced peritonitis

increased macrophage cell number ( J:301049 )

• in peritoneal tissues after LPS-induced peritonitis

• increased number of CD38+ pro-inflammatory macrophages in peritoneal tissues after LPS-induced peritonitis

cardiovascular system

abnormal retina vasculature morphology ( J:301119 )

• less retinal vasculature at age P5

hematopoietic system

hematopoietic system phenotype ( J:101679 , J:301049 )

N • physical examination, necropsy, histological examination of tissues and organs, bone marrow section evaluation, blood counts and differential cell counts, clinical chemistry panels, and densitometry reveal no differences from wildtype (J:101679)

N • normal number of monocytes in blood after LPS-induced peritonitis (J:301049)

increased macrophage cell number ( J:301049 )

• in peritoneal tissues after LPS-induced peritonitis

• increased number of CD38+ pro-inflammatory macrophages in peritoneal tissues after LPS-induced peritonitis

homeostasis/metabolism

impaired wound healing ( J:301119 )

• skin wound healing delayed at days 3-7 post-wounding

• larger wounds

vision/eye

abnormal retina vasculature morphology ( J:301119 )

• less retinal vasculature at age P5