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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc7a8tm1Dgen
targeted mutation 1, Deltagen
MGI:3604565
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Slc7a8tm1Dgen/Slc7a8tm1Dgen involves: 129P2/OlaHsd * C57BL/6 MGI:3606655


Genotype
MGI:3606655
hm1
Allelic
Composition		 Slc7a8tm1Dgen/Slc7a8tm1Dgen
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc7a8tm1Dgen mutation (1 available); any Slc7a8 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased susceptibility to pharmacologically induced seizures ( J:101679 )
• require an increased dose of metrazol to elicit the phase one seizure response compared to wildtype
impaired coordination ( J:101679 )
• exhibit a decrease in motor performance on the rotarod test
decreased locomotor activity ( J:101679 )
• exhibit a significant decrease in total distance traveled during open field testing

nervous system
decreased susceptibility to pharmacologically induced seizures ( J:101679 )
• require an increased dose of metrazol to elicit the phase one seizure response compared to wildtype




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory