Phenotypes associated with this allele

• Allele Symbol: Slc7a8^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:3604565
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc7a8^tm1Dgen/Slc7a8^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6	MGI:3606655

Genotype
MGI:3606655

hm1

• Allelic Composition: Slc7a8^tm1Dgen/Slc7a8^tm1Dgen
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased susceptibility to pharmacologically induced seizures ( J:101679 )

• require an increased dose of metrazol to elicit the phase one seizure response compared to wildtype

impaired coordination ( J:101679 )

• exhibit a decrease in motor performance on the rotarod test

decreased locomotor activity ( J:101679 )

• exhibit a significant decrease in total distance traveled during open field testing

nervous system

decreased susceptibility to pharmacologically induced seizures ( J:101679 )

• require an increased dose of metrazol to elicit the phase one seizure response compared to wildtype