About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ptch2tm1Dgen
targeted mutation 1, Deltagen
MGI:3604587
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ptch2tm1Dgen/Ptch2tm1Dgen involves: 129P2/OlaHsd * C57BL/6 MGI:3606646


Genotype
MGI:3606646
hm1
Allelic
Composition
Ptch2tm1Dgen/Ptch2tm1Dgen
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptch2tm1Dgen mutation (1 available); any Ptch2 mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• at 49 days of age spleen size, weight, and spleen weight to body weight ratio are increased in homozygous males
• a moderate to severe diffuse increase in extramedullary hematopoiesis is seen in homozygous males at 49 days of age
• in homozygous males at 49 days of age hemoglobin, hematocrit, and red blood cell count are decreased
• at 49 days of age the bone marrow myeloid:erythroid ratio is increased in homozygous males
• mild red blood cell abnormalities including anisocytosis, poikilocytosis, and polychromasia are seen in homozygous males at 49 days of age
• seen in homozygous males at 49 days of age
• seen in homozygous males at 49 days of age
• the percentage of neutrophils is mildly to moderately increased in homozygous males at 49 days of age

immune system
• at 49 days of age spleen size, weight, and spleen weight to body weight ratio are increased in homozygous males
• the percentage of neutrophils is mildly to moderately increased in homozygous males at 49 days of age

growth/size/body
• at 49 days of age spleen size, weight, and spleen weight to body weight ratio are increased in homozygous males





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory